A multiple sequence alignment among homologous and distant PLP enzymes was constructed on the basis of three dimensional structure superposition. The profile calculated from this alignment was able to detect similarities to the serine hydroxymethyltransferase family and to PLP/PMP dependent enzymes involved in the biosynthesis of dideoxy and aminosugars. Sequence alignments bertween the profile and these sequences showed the conservation of some essential residues.
Detection of weak structural similarities among PLP dependent enzymes / Pascarella, Stefano; Bossa, Francesco. - STAMPA. - (1994), pp. 21-25. (Intervento presentato al convegno International meeting on vitamin B6 and carbonyl catalysis tenutosi a Capri nel 22-27 maggio 1994).
Detection of weak structural similarities among PLP dependent enzymes
PASCARELLA, Stefano;BOSSA, Francesco
1994
Abstract
A multiple sequence alignment among homologous and distant PLP enzymes was constructed on the basis of three dimensional structure superposition. The profile calculated from this alignment was able to detect similarities to the serine hydroxymethyltransferase family and to PLP/PMP dependent enzymes involved in the biosynthesis of dideoxy and aminosugars. Sequence alignments bertween the profile and these sequences showed the conservation of some essential residues.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
