We designed this study to find out more about the relationship between the sensory effects of Botulinum toxin type A (BTX) and the clinical benefits of BTX therapy in patients with cervical dystonia (CD). In 24 patients with CD, we tested sensory temporal discrimination (STD) in the affected and two unaffected body regions (neck, hand, and eye) before and 1 month after BTX injection. In 8 out of the 24 patients with CD, STDT values were tested bilaterally in the three body regions before, 1 and 2 months after BTX injection. As expected, STD testing disclosed altered STD threshold values in all three body regions tested (affected and unaffected by dystonic spasms) in patients with CD. STD threshold values remained unchanged at all time points of the follow-up in all CD patients. The lack of BTX-induced effects on STD thresholds suggests that STD recruits neural structures uninvolved in muscle spindle afferent activation. (C) 2010 Movement Disorder Society

Somatosensory temporal discrimination tested in patients receiving botulinum toxin injection for cervical dystonia / Scontrini, Alessandra; Conte, Antonella; Fabbrini, Giovanni; Colosimo, Carlo; DI STASIO, Flavio; Ferrazzano, Gina; Berardelli, Alfredo. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - 26:4(2011), pp. 742-746. [10.1002/mds.23447]

Somatosensory temporal discrimination tested in patients receiving botulinum toxin injection for cervical dystonia

SCONTRINI, ALESSANDRA;CONTE, ANTONELLA;FABBRINI, Giovanni;COLOSIMO, Carlo;DI STASIO, FLAVIO;FERRAZZANO, GINA;BERARDELLI, Alfredo
2011

Abstract

We designed this study to find out more about the relationship between the sensory effects of Botulinum toxin type A (BTX) and the clinical benefits of BTX therapy in patients with cervical dystonia (CD). In 24 patients with CD, we tested sensory temporal discrimination (STD) in the affected and two unaffected body regions (neck, hand, and eye) before and 1 month after BTX injection. In 8 out of the 24 patients with CD, STDT values were tested bilaterally in the three body regions before, 1 and 2 months after BTX injection. As expected, STD testing disclosed altered STD threshold values in all three body regions tested (affected and unaffected by dystonic spasms) in patients with CD. STD threshold values remained unchanged at all time points of the follow-up in all CD patients. The lack of BTX-induced effects on STD thresholds suggests that STD recruits neural structures uninvolved in muscle spindle afferent activation. (C) 2010 Movement Disorder Society
2011
cervical dystonia; botulinum toxin; somatosensory temporal discrimination
01 Pubblicazione su rivista::01a Articolo in rivista
Somatosensory temporal discrimination tested in patients receiving botulinum toxin injection for cervical dystonia / Scontrini, Alessandra; Conte, Antonella; Fabbrini, Giovanni; Colosimo, Carlo; DI STASIO, Flavio; Ferrazzano, Gina; Berardelli, Alfredo. - In: MOVEMENT DISORDERS. - ISSN 0885-3185. - 26:4(2011), pp. 742-746. [10.1002/mds.23447]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/398836
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