An algorithm to determine the probability that a reading frame codifies for a protein is presented. It is based on the results of our previous studies on the thermodynamic characteristics of a translated reading frame. We also develop a prediction procedure to distinguish between coding and non-coding reading frames. The procedure is based on the characteristics of the putative product of the DNA sequence and not on periodicity characteristics of the sequence, so the prediction is not biased by the presence of overlapping translated reading frames or by the presence of translated reading frames on the complementary DNA strand.
Probability of coding of a DNA sequence: an algorithm to predict translated reading frames from their thermodynamic characteristics / Tramontano, Anna; M. F., Macchiato. - In: NUCLEIC ACIDS RESEARCH. - ISSN 0305-1048. - 14:(1986), pp. 127-135. [10.1093/nar/14.1.127]
Probability of coding of a DNA sequence: an algorithm to predict translated reading frames from their thermodynamic characteristics.
TRAMONTANO, ANNA;
1986
Abstract
An algorithm to determine the probability that a reading frame codifies for a protein is presented. It is based on the results of our previous studies on the thermodynamic characteristics of a translated reading frame. We also develop a prediction procedure to distinguish between coding and non-coding reading frames. The procedure is based on the characteristics of the putative product of the DNA sequence and not on periodicity characteristics of the sequence, so the prediction is not biased by the presence of overlapping translated reading frames or by the presence of translated reading frames on the complementary DNA strand.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
