Acute administration of desipramine, mianserin and viloxazine produces a significant decrease of locomotor activity in rats. Conversely, the locomotion of rats receiving the antidepressants for a prolonged period of time is not modified with respect to control animals. Moreover, the reserpine-induced decrement of locomotion is not influenced by chronic treatment with any of the antidepressants used in the present study. Since tolerance develops rapidly to these behavioural effects they may be indicative of compensatory changes in neuronal systems which may occur during prolonged antidepressant treatment. © 1983.
Behavioural changes after acute and chronic administration of typical and atypical antidepressants in rats: Interactions with reserpine / Cuomo, Vincenzo; R., Cagiano; N., Brunello; R., Fumagalli; G., Racagni. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 40:3(1983), pp. 315-319. [10.1016/0304-3940]
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
Titolo: | Behavioural changes after acute and chronic administration of typical and atypical antidepressants in rats: Interactions with reserpine | |
Autori: | ||
Data di pubblicazione: | 1983 | |
Rivista: | ||
Citazione: | Behavioural changes after acute and chronic administration of typical and atypical antidepressants in rats: Interactions with reserpine / Cuomo, Vincenzo; R., Cagiano; N., Brunello; R., Fumagalli; G., Racagni. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 40:3(1983), pp. 315-319. [10.1016/0304-3940] | |
Handle: | http://hdl.handle.net/11573/39825 | |
Appartiene alla tipologia: | 01a Articolo in rivista |