O-3-amino-3-deoxy-α -D-glucopyranosyl-(1→6)- O-[2,6-diamino-2,3,4,6-tetradeoxy -α-D-erythro-hexopyranohexopyranosyl- (1→4)]-2-deoxy-L-streptamine (dibekacin), like other known aminoglycoside antibiotics, possesses a dose-dependent neuromuscular blocking activity in vivo. d-Tubocurarine, at a dose which per se does not influence the contraction of gastrocnemius muscle elicited by sciatic nerve stimulation, significantly potentiates the neuromuscular blockade produced by dibekacin. Neostigmine methylsulfate is unable to reverse the neuromuscular blocking activity of dibekacin, whereas calcium chloride antagonizes the neuromuscular blockade produced by this antibiotic.

Effects of dibekacin, a new aminoglycoside antibiotic, on the rat sciatic nerve-gastrocnemius muscle preparation / G., Renna; G., Siro Brigiani; R., Cagiano; Cuomo, Vincenzo. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - STAMPA. - 34:11(1984), pp. 1540-1542.

Effects of dibekacin, a new aminoglycoside antibiotic, on the rat sciatic nerve-gastrocnemius muscle preparation

CUOMO, VINCENZO
1984

Abstract

O-3-amino-3-deoxy-α -D-glucopyranosyl-(1→6)- O-[2,6-diamino-2,3,4,6-tetradeoxy -α-D-erythro-hexopyranohexopyranosyl- (1→4)]-2-deoxy-L-streptamine (dibekacin), like other known aminoglycoside antibiotics, possesses a dose-dependent neuromuscular blocking activity in vivo. d-Tubocurarine, at a dose which per se does not influence the contraction of gastrocnemius muscle elicited by sciatic nerve stimulation, significantly potentiates the neuromuscular blockade produced by dibekacin. Neostigmine methylsulfate is unable to reverse the neuromuscular blocking activity of dibekacin, whereas calcium chloride antagonizes the neuromuscular blockade produced by this antibiotic.
1984
d-tubocurarine; dibekacin; gastrocnemius muscle; rat
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of dibekacin, a new aminoglycoside antibiotic, on the rat sciatic nerve-gastrocnemius muscle preparation / G., Renna; G., Siro Brigiani; R., Cagiano; Cuomo, Vincenzo. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - STAMPA. - 34:11(1984), pp. 1540-1542.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/39808
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