Behavioural responsiveness to muscimol and apomorphine two months after prolonged treatment with estradiol in rats

Cuomo, Vincenzo; Cagiano, R; Apud, J; Masotto, C; Racagni, G.

doi:10.1007/BF00427462

Two months after prolonged administration of estradiol (ES) in female rats the behavioural responsiveness to muscimol, a GABA receptor stimulating agent, and to apomorphine, a dopamine receptor agonist, was significantly altered. In particular, the decrease in locomotor activity induced by a challenge dose of muscimol (0.5-1 mg/kg) was significantly attenuated in ES-pretreated animals. Conversely, the intensity of stereotyped behaviour elicited by a challenge dose of apomorphine (1 mg/kg) was significantly increased in ES-pretreated rats. The behavioural alterations in the response to muscimol and apomorphine presumably result from the production of central GABA receptor subsensitivity and dopamine receptor supersensitivity respectively, induced by the prolonged ES administration.

Behavioural responsiveness to muscimol and apomorphine two months after prolonged treatment with estradiol in rats / Cuomo, Vincenzo; Cagiano, R; Apud, J; Masotto, C; Racagni, G.. - In: PSYCHOPHARMACOLOGY. - ISSN 0033-3158. - STAMPA. - 84(1984), pp. 287-288. [10.1007/BF00427462]

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Titolo:	Behavioural responsiveness to muscimol and apomorphine two months after prolonged treatment with estradiol in rats
Autori:	CUOMO, VINCENZO CAGIANO R APUD J MASOTTO C RACAGNI G. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1984
Rivista:	PSYCHOPHARMACOLOGY
Citazione:	Behavioural responsiveness to muscimol and apomorphine two months after prolonged treatment with estradiol in rats / Cuomo, Vincenzo; Cagiano, R; Apud, J; Masotto, C; Racagni, G.. - In: PSYCHOPHARMACOLOGY. - ISSN 0033-3158. - STAMPA. - 84(1984), pp. 287-288. [10.1007/BF00427462]
Handle:	http://hdl.handle.net/11573/39807
Appartiene alla tipologia:	01a Articolo in rivista

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