The long-term effects of perinatal Δ9-tetrahydrocannabinol (Δ9-THC) exposure - from gestational day (GD) 15 to postnatal day (PND) 9 - on hippocampal glutamatergic neurotransmission were studied in slices from the 40-day-old offspring of Δ9-THC exposed (Δ9-THC-rats) and vehicle-exposed (control) dams. Basal and in K+-evoked endogenous hippocampal glutamate outflow were both significantly decreased in Δ9-THC-rats. The effect of short Δ9-THC exposure (0.1 μM) on K+-evoked glutamate release disclosed a loss of the stimulatory effect of Δ9-THC on hippocampal glutamate release in Δ9-THC-rats, but not in controls. In addition, l-[3H]-glutamate uptake was significantly lower in hippocampal slices from Δ9-THC-rats, where a significant decrease in glutamate transporter 1 (GLT1) and glutamate/aspartate transporter (GLAST) protein was also detected. Collectively, these data demonstrate that perinatal exposure to cannabinoids induces long-term impairment in hippocampal glutamatergic neurotransmission that persist into adolescence. © 2009.

Altered regulation of glutamate release and decreased functional activity and expression of GLT1 and GLAST glutamate transporters in the hippocampus of adolescent rats perinatally exposed to Δ9-THC / Pasqualina, Castaldo; Simona, Magi; Mauro, Cataldi; Sara, Arcangeli; W., Capeci; Luca, Ferraro; Maria Cristina, Tomasini; Tiziana, Antonelli; Tommaso, Cassano; Cuomo, Vincenzo; Salvatore, Amoroso. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 61:4(2010), pp. 334-341. [10.1016/j.phrs.2009.11.008]

Altered regulation of glutamate release and decreased functional activity and expression of GLT1 and GLAST glutamate transporters in the hippocampus of adolescent rats perinatally exposed to Δ9-THC

CUOMO, VINCENZO;
2010

Abstract

The long-term effects of perinatal Δ9-tetrahydrocannabinol (Δ9-THC) exposure - from gestational day (GD) 15 to postnatal day (PND) 9 - on hippocampal glutamatergic neurotransmission were studied in slices from the 40-day-old offspring of Δ9-THC exposed (Δ9-THC-rats) and vehicle-exposed (control) dams. Basal and in K+-evoked endogenous hippocampal glutamate outflow were both significantly decreased in Δ9-THC-rats. The effect of short Δ9-THC exposure (0.1 μM) on K+-evoked glutamate release disclosed a loss of the stimulatory effect of Δ9-THC on hippocampal glutamate release in Δ9-THC-rats, but not in controls. In addition, l-[3H]-glutamate uptake was significantly lower in hippocampal slices from Δ9-THC-rats, where a significant decrease in glutamate transporter 1 (GLT1) and glutamate/aspartate transporter (GLAST) protein was also detected. Collectively, these data demonstrate that perinatal exposure to cannabinoids induces long-term impairment in hippocampal glutamatergic neurotransmission that persist into adolescence. © 2009.
delta(9)-thc; glt1 and glast; glutamate release; hippocampus; perinatal exposure; δ9-thc
01 Pubblicazione su rivista::01a Articolo in rivista
Altered regulation of glutamate release and decreased functional activity and expression of GLT1 and GLAST glutamate transporters in the hippocampus of adolescent rats perinatally exposed to Δ9-THC / Pasqualina, Castaldo; Simona, Magi; Mauro, Cataldi; Sara, Arcangeli; W., Capeci; Luca, Ferraro; Maria Cristina, Tomasini; Tiziana, Antonelli; Tommaso, Cassano; Cuomo, Vincenzo; Salvatore, Amoroso. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 61:4(2010), pp. 334-341. [10.1016/j.phrs.2009.11.008]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/39694
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 20
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 31
social impact