Parkinson’s disease is characterized by a progressive and selective loss of dopaminergic neurons in the Substantia nigra. Recent studies indicate that 5-S-cysteinyldopamine (CysDA) is strongly neurotoxic and may contribute to the onset and progression of this disease. The aim of the present work is to study the effect exerted by CysDA on the expression, aggregation and cellular localization of alpha-Synuclein (a-Syn), involved in the etiopathogenesis of PD, and of ERp57, an endoplasmic reticulum thiol oxidoreductase, known to be implicated in neurodegeneration.
Modulation of the expression and aggregation of alpha-synuclein and of ERp57 in cellular and animal models of Parkinson disease / Aureli, Cristina; Francioso, A.; Masci, A.; Faraldi, M.; Martire, S.; Ferraro, Anna; Fontana, Mario; D'Erme, Maria; Mosca, Luciana. - In: THE FEBS JOURNAL. - ISSN 1742-4658. - STAMPA. - 27:(2011), pp. 257-257. (Intervento presentato al convegno 36th FEBS Congress, Biochemistry for Tomorrow's Medicine tenutosi a Torino nel 25-30 giugno 2011) [10.1111/j.1742-4658.2011.08137.x].
Modulation of the expression and aggregation of alpha-synuclein and of ERp57 in cellular and animal models of Parkinson disease.
AURELI, CRISTINA;Francioso A.;FERRARO, Anna;FONTANA, Mario;D'ERME, Maria;MOSCA, Luciana
2011
Abstract
Parkinson’s disease is characterized by a progressive and selective loss of dopaminergic neurons in the Substantia nigra. Recent studies indicate that 5-S-cysteinyldopamine (CysDA) is strongly neurotoxic and may contribute to the onset and progression of this disease. The aim of the present work is to study the effect exerted by CysDA on the expression, aggregation and cellular localization of alpha-Synuclein (a-Syn), involved in the etiopathogenesis of PD, and of ERp57, an endoplasmic reticulum thiol oxidoreductase, known to be implicated in neurodegeneration.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
