Human platelets may hydrolyze externally added NAD yielding ADP-ribose and nicotinamide. The extent of hydrolysis is significantly higher when the platelets are stimulated. The presence of external NAD strongly inhibits the aggregation induced by every agonist used. Adenosine or ADP-ribose itself generated by NAD hydrolysis may be responsible for the inhibition of aggregation. Evidently, some of the NAD hydrolysis product is taken up by stimulated platelets.
A surface NAD-glycohydrolase of human platelets may influence their aggregation / Del Principe, D.; Menichelli, A.; Casini, Antonio; Di Giulio, S.; Mancuso, G.; Finazzi Agro, A.. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 205:(1986), pp. 66-70.
A surface NAD-glycohydrolase of human platelets may influence their aggregation.
CASINI, Antonio;
1986
Abstract
Human platelets may hydrolyze externally added NAD yielding ADP-ribose and nicotinamide. The extent of hydrolysis is significantly higher when the platelets are stimulated. The presence of external NAD strongly inhibits the aggregation induced by every agonist used. Adenosine or ADP-ribose itself generated by NAD hydrolysis may be responsible for the inhibition of aggregation. Evidently, some of the NAD hydrolysis product is taken up by stimulated platelets.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
