Experimental evidence suggests that the prokaryotic respiratory cytochrome bd quinol oxidase is responsible for both bioenergetic functions and bacterial adaptation to different stress conditions. The enzyme, phylogenetically unrelated to the extensively studied heme-copper terminal oxidases, is found in many commensal and pathogenic bacteria. Here, we review current knowledge on the catalytic intermediates of cytochrome bd and their reactivity towards nitric oxide (NO). Available information is discussed in the light of the hypothesis that, owing to its high NO dissociation rate, cytochrome bd confers resistance to NO-stress, thereby providing a strategy for bacterial pathogens to evade the NO-mediated host immune attack. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

Cytochrome bd oxidase and nitric oxide: From reaction mechanisms to bacterial physiology / Giuffre', Alessandro; Vitaliy B., Borisov; Mastronicola, Daniela; Sarti, Paolo; Forte, Elena. - In: FEBS LETTERS. - ISSN 0014-5793. - 586:5(2012), pp. 622-629. [10.1016/j.febslet.2011.07.035]

Cytochrome bd oxidase and nitric oxide: From reaction mechanisms to bacterial physiology

GIUFFRE', ALESSANDRO;MASTRONICOLA, Daniela;SARTI, Paolo;FORTE, Elena
2012

Abstract

Experimental evidence suggests that the prokaryotic respiratory cytochrome bd quinol oxidase is responsible for both bioenergetic functions and bacterial adaptation to different stress conditions. The enzyme, phylogenetically unrelated to the extensively studied heme-copper terminal oxidases, is found in many commensal and pathogenic bacteria. Here, we review current knowledge on the catalytic intermediates of cytochrome bd and their reactivity towards nitric oxide (NO). Available information is discussed in the light of the hypothesis that, owing to its high NO dissociation rate, cytochrome bd confers resistance to NO-stress, thereby providing a strategy for bacterial pathogens to evade the NO-mediated host immune attack. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
2012
bacterial pathogen; catalytic intermediate; hemeprotein; nitrosative stress; respiratory chain
01 Pubblicazione su rivista::01a Articolo in rivista
Cytochrome bd oxidase and nitric oxide: From reaction mechanisms to bacterial physiology / Giuffre', Alessandro; Vitaliy B., Borisov; Mastronicola, Daniela; Sarti, Paolo; Forte, Elena. - In: FEBS LETTERS. - ISSN 0014-5793. - 586:5(2012), pp. 622-629. [10.1016/j.febslet.2011.07.035]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/395931
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