The relation between coagulation indexes and survival rate was studied and analyzed in 46 patients with advanced liver cirrhosis (grade B and C Child-Pugh Classification), during a follow-up of 1 year. Twenty-four patients (52%) died of liver failure or fatal haemorrhage within 12 months of follow-up. Prothrombin activity, fibrinogen, fibrin(ogen) degradation products, prekallikrein and factor VII, serum bilirubin, and the degree of liver insufficiency, scored by Child-Pugh classification, proved to be significantly correlated with survival by univariate analysis. A multivariate survival analysis (Cox regression model) disclosed two variables, prekallikrein and factor VII, that predicted survival. The rate ratios of death increased to 2.8 and 7.6 with values of prekallikrein < 26% and factor VII < 39%, respectively. This study shows that some simple laboratory tests exploring the clotting system may identify patients with poor prognosis in severe liver failure.

1-YEAR SURVEY OF PATIENTS WITH ADVANCED LIVER-CIRRHOSIS - PROGNOSTIC VALUE OF CLINICAL AND LABORATORY INDEXES IDENTIFIED BY THE COX REGRESSION-MODEL / Ferro, Domenico; Saliola, Mirella; C., Quintarelli; Alessandri, Cesare; Basili, Stefania; C., Cordova; M. S., Bonavita; Violi, Francesco. - In: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0036-5521. - 27:10(1992), pp. 852-856. [10.3109/00365529209000153]

1-YEAR SURVEY OF PATIENTS WITH ADVANCED LIVER-CIRRHOSIS - PROGNOSTIC VALUE OF CLINICAL AND LABORATORY INDEXES IDENTIFIED BY THE COX REGRESSION-MODEL

FERRO, Domenico;SALIOLA, Mirella;ALESSANDRI, Cesare;BASILI, Stefania;VIOLI, Francesco
1992

Abstract

The relation between coagulation indexes and survival rate was studied and analyzed in 46 patients with advanced liver cirrhosis (grade B and C Child-Pugh Classification), during a follow-up of 1 year. Twenty-four patients (52%) died of liver failure or fatal haemorrhage within 12 months of follow-up. Prothrombin activity, fibrinogen, fibrin(ogen) degradation products, prekallikrein and factor VII, serum bilirubin, and the degree of liver insufficiency, scored by Child-Pugh classification, proved to be significantly correlated with survival by univariate analysis. A multivariate survival analysis (Cox regression model) disclosed two variables, prekallikrein and factor VII, that predicted survival. The rate ratios of death increased to 2.8 and 7.6 with values of prekallikrein < 26% and factor VII < 39%, respectively. This study shows that some simple laboratory tests exploring the clotting system may identify patients with poor prognosis in severe liver failure.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/394893
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