In patients with chronic liver disease (CLD), several clotting changes can be observed. The most frequent abnormality is the reduced synthesis of many clotting factors, including vitamin-K-dependent and vitamin-K-independent ones. A low platelet count is another frequent feature of patients with CLD, which, however, is not always associated with the prolongation of bleeding time. Hyperfibrinolytic syndrome is usually seen in patients with decompensated state, and may further deteriorate the clotting abnormalities and favor bleeding complications. The assessment of the clotting system may be a useful approach to evaluate liver function and predict prognosis of patients with CLD.
CLOTTING ABNORMALITIES IN CHRONIC LIVER-DISEASE / Violi, Francesco; Ferro, Domenico; Claudio, Quintarelli; Mirella, Saliola; Corrado, Cordova; Francesco, Balsano. - In: DIGESTIVE DISEASES. - ISSN 0257-2753. - 10:3(1992), pp. 162-172. [10.1159/000171354]
CLOTTING ABNORMALITIES IN CHRONIC LIVER-DISEASE
VIOLI, Francesco;FERRO, Domenico;
1992
Abstract
In patients with chronic liver disease (CLD), several clotting changes can be observed. The most frequent abnormality is the reduced synthesis of many clotting factors, including vitamin-K-dependent and vitamin-K-independent ones. A low platelet count is another frequent feature of patients with CLD, which, however, is not always associated with the prolongation of bleeding time. Hyperfibrinolytic syndrome is usually seen in patients with decompensated state, and may further deteriorate the clotting abnormalities and favor bleeding complications. The assessment of the clotting system may be a useful approach to evaluate liver function and predict prognosis of patients with CLD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
