VIN usual type appears to be related to the HPV's oncogenic types. The aim of this prospective multicenter study was to evaluate the re-infection rate of high-risk HPV and the recurrence rate of VIN usual type after surgical treatment. The study enrolled 103 women affected by VIN usual type. They underwent wide local excision by CO2 laser. The patients were investigated by clinical evaluation and HPV DNA test 6 months after surgical treatment, and then were followed-up at 12, 18, 24, and 36 months. The recurrences were treated with re-excision. The rate of HPV infection after surgical treatment was 34% at 6 months, 36.9% at 12 months, 40% at 18 months, 41.7% at 24 months and 44.7% at 36 months. The mean time from HPV infection to the development of VIN was 18.8 months. HPV testing in the follow-up of VIN usual type patients might be useful for identifying those patients with a higher risk of recurrence after surgical treatment, although more studies are needed. These preliminary data suggest that the test, in addition to clinical examination, can improve the efficacy of the follow-up.

The re-infection rate of high-risk HPV and the recurrence rate of vulvar intraepithelial neoplasia (VIN) usual type after surgical treatment / Frega, Antonio; Francesco, Sopracordevole; Paolo, Scirpa; Alberto, Biamonti; Lorenzon, Laura; Simona, Scarani; Luana De, Sanctis; Pacchiarotti, Arianna; Moscarini, Massimo; French, Deborah; Scarani, Simona; DE SANCTIS, Luana. - In: MEDICAL SCIENCE MONITOR. - ISSN 1234-1010. - 17:9(2011), pp. CR532-CR535. [10.12659/msm.881941]

The re-infection rate of high-risk HPV and the recurrence rate of vulvar intraepithelial neoplasia (VIN) usual type after surgical treatment

FREGA, Antonio;LORENZON, LAURA;PACCHIAROTTI, ARIANNA;MOSCARINI, Massimo;FRENCH, Deborah;SCARANI, SIMONA;DE SANCTIS, LUANA
2011

Abstract

VIN usual type appears to be related to the HPV's oncogenic types. The aim of this prospective multicenter study was to evaluate the re-infection rate of high-risk HPV and the recurrence rate of VIN usual type after surgical treatment. The study enrolled 103 women affected by VIN usual type. They underwent wide local excision by CO2 laser. The patients were investigated by clinical evaluation and HPV DNA test 6 months after surgical treatment, and then were followed-up at 12, 18, 24, and 36 months. The recurrences were treated with re-excision. The rate of HPV infection after surgical treatment was 34% at 6 months, 36.9% at 12 months, 40% at 18 months, 41.7% at 24 months and 44.7% at 36 months. The mean time from HPV infection to the development of VIN was 18.8 months. HPV testing in the follow-up of VIN usual type patients might be useful for identifying those patients with a higher risk of recurrence after surgical treatment, although more studies are needed. These preliminary data suggest that the test, in addition to clinical examination, can improve the efficacy of the follow-up.
2011
vin usual type; human papillomavirus (hpv); hpv dna test
01 Pubblicazione su rivista::01a Articolo in rivista
The re-infection rate of high-risk HPV and the recurrence rate of vulvar intraepithelial neoplasia (VIN) usual type after surgical treatment / Frega, Antonio; Francesco, Sopracordevole; Paolo, Scirpa; Alberto, Biamonti; Lorenzon, Laura; Simona, Scarani; Luana De, Sanctis; Pacchiarotti, Arianna; Moscarini, Massimo; French, Deborah; Scarani, Simona; DE SANCTIS, Luana. - In: MEDICAL SCIENCE MONITOR. - ISSN 1234-1010. - 17:9(2011), pp. CR532-CR535. [10.12659/msm.881941]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/393824
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