Studies dealing with the outcomes of developmental carbon monoxide (CO) exposure on myelination in rat offspring are reviewed. Prenatal CO exposure from gestational day 0 to gestational day 20 impairs myelin deposition around peripheral axons resulting in a significant hypomyelination in juvenile and adult rats. Myelin protein patterns analyzed by SDS-polyacrylamide gel electrophoresis and lipid patterns analyzed by the HPTLC method are not altered in both peripheral and central nervous systems of CO-exposed offspring. Interestingly, when sphingomyelin is extracted and purified, the derivatization by OPA reagent and analysis by reversed-phase HPLC reveal a significant increase in sphingosine levels in peripheral nervous system but not in central nervous system of CO-exposed rats. The above morphological and biochemical alterations are not accompanied by motor disabilities. Copyright © 2007 S. Karger AG.
Smoking during pregnancy: A risk factor for peripheral neuropathy? / M. R., Carratu'; A., Coluccia; P., Borracci; A., Fasano; P., Riccio; Cuomo, Vincenzo. - In: DEVELOPMENTAL NEUROSCIENCE. - ISSN 0378-5866. - STAMPA. - 30:4(2008), pp. 224-230. [10.1159/000110501]
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Titolo: | Smoking during pregnancy: A risk factor for peripheral neuropathy? | |
Autori: | ||
Data di pubblicazione: | 2008 | |
Rivista: | ||
Citazione: | Smoking during pregnancy: A risk factor for peripheral neuropathy? / M. R., Carratu'; A., Coluccia; P., Borracci; A., Fasano; P., Riccio; Cuomo, Vincenzo. - In: DEVELOPMENTAL NEUROSCIENCE. - ISSN 0378-5866. - STAMPA. - 30:4(2008), pp. 224-230. [10.1159/000110501] | |
Handle: | http://hdl.handle.net/11573/39359 | |
Appartiene alla tipologia: | 01a Articolo in rivista |