Smoking during pregnancy: A risk factor for peripheral neuropathy?

Carratu', M. R.; Coluccia, A.; Borracci, P.; Fasano, A.; Riccio, P.; Cuomo, Vincenzo

doi:10.1159/000110501

Studies dealing with the outcomes of developmental carbon monoxide (CO) exposure on myelination in rat offspring are reviewed. Prenatal CO exposure from gestational day 0 to gestational day 20 impairs myelin deposition around peripheral axons resulting in a significant hypomyelination in juvenile and adult rats. Myelin protein patterns analyzed by SDS-polyacrylamide gel electrophoresis and lipid patterns analyzed by the HPTLC method are not altered in both peripheral and central nervous systems of CO-exposed offspring. Interestingly, when sphingomyelin is extracted and purified, the derivatization by OPA reagent and analysis by reversed-phase HPLC reveal a significant increase in sphingosine levels in peripheral nervous system but not in central nervous system of CO-exposed rats. The above morphological and biochemical alterations are not accompanied by motor disabilities. Copyright © 2007 S. Karger AG.

Smoking during pregnancy: A risk factor for peripheral neuropathy? / M. R., Carratu'; A., Coluccia; P., Borracci; A., Fasano; P., Riccio; Cuomo, Vincenzo. - In: DEVELOPMENTAL NEUROSCIENCE. - ISSN 0378-5866. - STAMPA. - 30:4(2008), pp. 224-230.

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Titolo:	Smoking during pregnancy: A risk factor for peripheral neuropathy?
Autori:	M. R. Carratu' A. Coluccia P. Borracci A. Fasano P. Riccio CUOMO, VINCENZO mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2008
Rivista:	DEVELOPMENTAL NEUROSCIENCE
Citazione:	Smoking during pregnancy: A risk factor for peripheral neuropathy? / M. R., Carratu'; A., Coluccia; P., Borracci; A., Fasano; P., Riccio; Cuomo, Vincenzo. - In: DEVELOPMENTAL NEUROSCIENCE. - ISSN 0378-5866. - STAMPA. - 30:4(2008), pp. 224-230.
Handle:	http://hdl.handle.net/11573/39359
Appartiene alla tipologia:	01a Articolo in rivista

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