Acute colonic pseudo-obstruction, the so-called Ogilvie's syndrome, is a rare and life-threatening digestive complication usually observed in critically ill patients. It is characterized by signs of large-bowel obstruction, without a mechanical cause, and has been reported in various settings, including acute leukemias as a complication of neutropenic enterocolitis after intensive chemotherapy. We describe the case of a young woman who, during the neutropenic phase following autologous bone marrow transplantation for relapsed acute myeloid leukemia, developed neutropenic enterocolitis complicated by an acute pseudo-obstruction of descendent colon and sigma. This process was associated with sepsis and resolved with conservative therapy of the underlying condition, using granulocyte colony-stimulating factor and intravenous neostigmine. We discuss the management of this rare syndrome.

Ogilvie’s syndrome in acute myeloid leukemia: pharmacological approach with neostigmine / M., Breccia; C., Girmenia; S., Mecarocci; C., Cartoni; I., Carmosino; Tafuri, Agostino; Alimena, Giuliana. - In: ANNALS OF HEMATOLOGY. - ISSN 0939-5555. - 80:10(2001), pp. 614-616.

Ogilvie’s syndrome in acute myeloid leukemia: pharmacological approach with neostigmine.

M. Breccia;TAFURI, Agostino;ALIMENA, Giuliana
2001

Abstract

Acute colonic pseudo-obstruction, the so-called Ogilvie's syndrome, is a rare and life-threatening digestive complication usually observed in critically ill patients. It is characterized by signs of large-bowel obstruction, without a mechanical cause, and has been reported in various settings, including acute leukemias as a complication of neutropenic enterocolitis after intensive chemotherapy. We describe the case of a young woman who, during the neutropenic phase following autologous bone marrow transplantation for relapsed acute myeloid leukemia, developed neutropenic enterocolitis complicated by an acute pseudo-obstruction of descendent colon and sigma. This process was associated with sepsis and resolved with conservative therapy of the underlying condition, using granulocyte colony-stimulating factor and intravenous neostigmine. We discuss the management of this rare syndrome.
2001
neutropenic enterocolitis, acute myeloid leukemia, Ogilvie's syndrome, neostigmine
01 Pubblicazione su rivista::01a Articolo in rivista
Ogilvie’s syndrome in acute myeloid leukemia: pharmacological approach with neostigmine / M., Breccia; C., Girmenia; S., Mecarocci; C., Cartoni; I., Carmosino; Tafuri, Agostino; Alimena, Giuliana. - In: ANNALS OF HEMATOLOGY. - ISSN 0939-5555. - 80:10(2001), pp. 614-616.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/391389
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