The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent manner. In addition, rIL-2 (1000 U/ml) reduced both post-tetanic potentiation (PTP) and LTP maintenance phase. The possible involvement of rIL-2 action on the synaptic potentiation with the enzymatic activity of protein kinase systems is discussed.
INTERLEUKIN-2 SUPPRESSES ESTABLISHED LONG-TERM POTENTIATION AND INHIBITS ITS INDUCTION IN THE RAT HIPPOCAMPUS / Virginia, Tancredi; Cristina, Zona; Velotti, Francesca Romana; Eusebi, Fabrizio; Santoni, Angela. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 525:1(1990), pp. 149-151. [10.1016/0006-8993(90)91331-a]
INTERLEUKIN-2 SUPPRESSES ESTABLISHED LONG-TERM POTENTIATION AND INHIBITS ITS INDUCTION IN THE RAT HIPPOCAMPUS
VELOTTI, Francesca Romana;EUSEBI, Fabrizio;SANTONI, Angela
1990
Abstract
The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent manner. In addition, rIL-2 (1000 U/ml) reduced both post-tetanic potentiation (PTP) and LTP maintenance phase. The possible involvement of rIL-2 action on the synaptic potentiation with the enzymatic activity of protein kinase systems is discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
