CD69 was initially described as being restricted to recently activated lymphoid cells, brat is now known to be expressed on the surface of all hematopoietically derived leukocytes. Crosslinking of CD69 generates intracellular signals in all cell lineages studied, both mouse and human, and results in a variety of cellular end I responses. Since a specific ligand has not yet been identified, a definite functional identity for CD69 is still missing. However, as discussed here by Roberto Testi and colleagues, the broad expression of CD69 and its conserved ability to generate intracellular signals suggests a general role for the CD69 receptor in the biology of hematopoietic cells.
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|Titolo:||The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells.|
|Data di pubblicazione:||1994|
|Citazione:||The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. / Testi, R; D'Ambrosio, D; De Maria, R; Santoni, Angela. - In: IMMUNOLOGY TODAY. - ISSN 0167-5699. - STAMPA. - 15(1994), pp. 479-483.|
|Appartiene alla tipologia:||01a Articolo in rivista|