B-Endorphin (B-Ep), ACTH and cortisol circulating levels, before and after a two months therapy with a hypocaloric diet and an increase in physical exercise, were measured by RIA in 17 obese female subjects. After therapy, the body weight excess fell from 56.6±22.2% to 38.6±22.1% (p<0.01). Plasma levels of B-Ep decreased from 18.3±12.5 fmol/ml to 6.4±3.5 fmol/ml (p<0.01); those of ACTH from 46.8±22.8 pg/ml to 31.2±11.6 pg/ml (p<0.01); and those of cortisol from 15.9±4.6 μg% to 10.3±2.5 μg% (p<0.01). The reduction of the elevated plasma B-Ep levels found in obese subjects is related principally to the diet therapy. Thus, as shown in experimental animals, excessive feeding results in an increased hypothalamic-pituitary secretion of B-Ep.
EFFECTS OF CALORIC RESTRICTION AND EXERCISE ON B-ENDORPHIN, ACTH AND CORTISOL CIRCULATING LEVELS IN OBESITY / D., Scavo; C., Barletta; Buzzetti, Raffaella; D., Vagiri. - In: PHYSIOLOGY & BEHAVIOR. - ISSN 0031-9384. - 42:1(1988), pp. 65-68. [10.1016/0031-9384(88)90261-2]
EFFECTS OF CALORIC RESTRICTION AND EXERCISE ON B-ENDORPHIN, ACTH AND CORTISOL CIRCULATING LEVELS IN OBESITY
BUZZETTI, Raffaella;
1988
Abstract
B-Endorphin (B-Ep), ACTH and cortisol circulating levels, before and after a two months therapy with a hypocaloric diet and an increase in physical exercise, were measured by RIA in 17 obese female subjects. After therapy, the body weight excess fell from 56.6±22.2% to 38.6±22.1% (p<0.01). Plasma levels of B-Ep decreased from 18.3±12.5 fmol/ml to 6.4±3.5 fmol/ml (p<0.01); those of ACTH from 46.8±22.8 pg/ml to 31.2±11.6 pg/ml (p<0.01); and those of cortisol from 15.9±4.6 μg% to 10.3±2.5 μg% (p<0.01). The reduction of the elevated plasma B-Ep levels found in obese subjects is related principally to the diet therapy. Thus, as shown in experimental animals, excessive feeding results in an increased hypothalamic-pituitary secretion of B-Ep.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
