The association between bronchiolitis and recurrent wheezing remains controversial. In this prospective study, we assessed risk factors for recurrent wheezing during a 12-month follow-up in 313 infants aged <12 months hospitalised for their first episode of bronchiolitis. Demographic, clinical and laboratory data were obtained with a questionnaire and from medical files. A total of 14 respiratory viruses were concurrently assayed in nasal washings. Parents were interviewed 12 months after hospitalisation to check whether their infants experienced recurrent wheezing. The rate of recurrent wheezing was higher in infants with bronchiolitis than in controls (52.7 versus 10.3%; p<0.001). Multivariate analysis identified rhinovirus (RV) infection (OR 3.3, 95% CI 1.0-11.1) followed by a positive family history for asthma (OR 2.5, 95% CI 1.2-4.9) as major independent risk factors for recurrent wheezing. In conclusion, the virus most likely to be associated with recurrent wheezing at 12 months after initial bronchiolitis is RV, a viral agent that could predict infants prone to the development of recurrent wheezing.

Rhinovirus bronchiolitis and recurrent wheezing: one year follow-up / Midulla, Fabio; Pierangeli, Alessandra; Cangiano, Giulia; Bonci, Enea; Salvadei, S.; Scagnolari, Carolina; Moretti, Corrado; Antonelli, Guido; Ferro, VALENTINA ANNAROSA; Papoff, Paola. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - STAMPA. - 39:2(2012), pp. 396-402. [10.1183/09031936.00188210]

Rhinovirus bronchiolitis and recurrent wheezing: one year follow-up

MIDULLA, Fabio;PIERANGELI, Alessandra;CANGIANO, GIULIA;BONCI, Enea;SCAGNOLARI, CAROLINA;MORETTI, Corrado;ANTONELLI, Guido;FERRO, VALENTINA ANNAROSA;PAPOFF, PAOLA
2012

Abstract

The association between bronchiolitis and recurrent wheezing remains controversial. In this prospective study, we assessed risk factors for recurrent wheezing during a 12-month follow-up in 313 infants aged <12 months hospitalised for their first episode of bronchiolitis. Demographic, clinical and laboratory data were obtained with a questionnaire and from medical files. A total of 14 respiratory viruses were concurrently assayed in nasal washings. Parents were interviewed 12 months after hospitalisation to check whether their infants experienced recurrent wheezing. The rate of recurrent wheezing was higher in infants with bronchiolitis than in controls (52.7 versus 10.3%; p<0.001). Multivariate analysis identified rhinovirus (RV) infection (OR 3.3, 95% CI 1.0-11.1) followed by a positive family history for asthma (OR 2.5, 95% CI 1.2-4.9) as major independent risk factors for recurrent wheezing. In conclusion, the virus most likely to be associated with recurrent wheezing at 12 months after initial bronchiolitis is RV, a viral agent that could predict infants prone to the development of recurrent wheezing.
2012
01 Pubblicazione su rivista::01a Articolo in rivista
Rhinovirus bronchiolitis and recurrent wheezing: one year follow-up / Midulla, Fabio; Pierangeli, Alessandra; Cangiano, Giulia; Bonci, Enea; Salvadei, S.; Scagnolari, Carolina; Moretti, Corrado; Antonelli, Guido; Ferro, VALENTINA ANNAROSA; Papoff, Paola. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - STAMPA. - 39:2(2012), pp. 396-402. [10.1183/09031936.00188210]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/390020
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 55
  • Scopus 105
  • ???jsp.display-item.citation.isi??? 92
social impact