Background: Many studies have reported an increased risk of developing a second primary malignancy (SPM) of the breast in women treated for thyroid cancer. In this study, we investigated several potential risk factors for this association. The aim of this retrospective cohort study was to identify a subgroup of women surgically treated for papillary thyroid cancer that may benefit from more careful breast cancer screening. Methods: A total of 101 women surgically treated for papillary thyroid cancer from 1996 to 2009 with subsequent follow-up were interviewed by phone regarding personal risk factors and lifestyle habits. Only 75 questionnaires could be evaluated due to a 25.7% rate of patients not retrieved or refusing the interview. Data analysis was performed using a multivariate logistic model. Results: The standardised incidence ratio (SIR) for breast cancer was 3.58 (95% IC 1.14 - 8.37). Our data suggest a protective effect of multiparity on the development of a SPM of the breast (O.R. 0.15; 95% IC 0.25 - 0.86). Significant associations were not found with other known risk factors including Body Mass Index (BMI), age at first tumour, concurrent metabolic diseases, smoking, physical activity and familiarity. Conclusions: This study confirms that a higher incidence of SPM of the breast is observed in women treated for papillary thyroid cancer. Additionally, this risk is increased by nulliparity, thus a strict breast screening program for nulliparous women treated for thyroid cancer may be advisable.

Nulliparity enhances the risk of second primary malignancy of the breast in a cohort of women treated for thyroid cancer / Consorti, Fabrizio; DI TANNA, GIAN LUCA; Francesca, Milazzo; Antonaci, Alfredo. - In: WORLD JOURNAL OF SURGICAL ONCOLOGY. - ISSN 1477-7819. - STAMPA. - 9:1(2011), p. 88. [10.1186/1477-7819-9-88]

Nulliparity enhances the risk of second primary malignancy of the breast in a cohort of women treated for thyroid cancer

CONSORTI, Fabrizio;DI TANNA, GIAN LUCA;ANTONACI, Alfredo
2011

Abstract

Background: Many studies have reported an increased risk of developing a second primary malignancy (SPM) of the breast in women treated for thyroid cancer. In this study, we investigated several potential risk factors for this association. The aim of this retrospective cohort study was to identify a subgroup of women surgically treated for papillary thyroid cancer that may benefit from more careful breast cancer screening. Methods: A total of 101 women surgically treated for papillary thyroid cancer from 1996 to 2009 with subsequent follow-up were interviewed by phone regarding personal risk factors and lifestyle habits. Only 75 questionnaires could be evaluated due to a 25.7% rate of patients not retrieved or refusing the interview. Data analysis was performed using a multivariate logistic model. Results: The standardised incidence ratio (SIR) for breast cancer was 3.58 (95% IC 1.14 - 8.37). Our data suggest a protective effect of multiparity on the development of a SPM of the breast (O.R. 0.15; 95% IC 0.25 - 0.86). Significant associations were not found with other known risk factors including Body Mass Index (BMI), age at first tumour, concurrent metabolic diseases, smoking, physical activity and familiarity. Conclusions: This study confirms that a higher incidence of SPM of the breast is observed in women treated for papillary thyroid cancer. Additionally, this risk is increased by nulliparity, thus a strict breast screening program for nulliparous women treated for thyroid cancer may be advisable.
2011
breast cancer; thyroid cancer; second primary malignancy; risk factor
01 Pubblicazione su rivista::01a Articolo in rivista
Nulliparity enhances the risk of second primary malignancy of the breast in a cohort of women treated for thyroid cancer / Consorti, Fabrizio; DI TANNA, GIAN LUCA; Francesca, Milazzo; Antonaci, Alfredo. - In: WORLD JOURNAL OF SURGICAL ONCOLOGY. - ISSN 1477-7819. - STAMPA. - 9:1(2011), p. 88. [10.1186/1477-7819-9-88]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/389859
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