Using in situ hybridization (ISH), we studied the distribution of rat glucocorticoid receptors (GR) mRNA in rat spinal cord. mRNA encoding for GR was abundant throughout the white matter and a clear pattern of distribution was detected within the grey matter. In the grey matter mRNA was primarily localized in the ventral horn, where motoneurones were strongly labelled. In the dorsal horn, the distribution appears more diffuse but the superficial layers (I and II) clearly exhibited a shigher signal. We conclude that, in rat spinal cord, GR are present in both glial and neuronal cells. In particular, both somatosensory and motor pathways contain GR.
Distribution of glucocorticoid receptor mRNA in the rat spinal cord / Lionel N. J. L., Marlier; Tamás, Csikos; Nicoletta, Rebaudengo; Patrizia, Borboni; Patacchioli, Francesca Romana; Angelucci, Luciano; Alain, Privat; Renato, Lauro. - In: NEUROREPORT. - ISSN 0959-4965. - STAMPA. - 6:16(1995), pp. 2245-2249. [10.1097/00001756-199511000-00034]
Distribution of glucocorticoid receptor mRNA in the rat spinal cord
PATACCHIOLI, Francesca Romana;ANGELUCCI, Luciano;
1995
Abstract
Using in situ hybridization (ISH), we studied the distribution of rat glucocorticoid receptors (GR) mRNA in rat spinal cord. mRNA encoding for GR was abundant throughout the white matter and a clear pattern of distribution was detected within the grey matter. In the grey matter mRNA was primarily localized in the ventral horn, where motoneurones were strongly labelled. In the dorsal horn, the distribution appears more diffuse but the superficial layers (I and II) clearly exhibited a shigher signal. We conclude that, in rat spinal cord, GR are present in both glial and neuronal cells. In particular, both somatosensory and motor pathways contain GR.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
