A new preparation and the isolation and spectroscopic characterization of 1,3,3-trimethylbicyclo[2.2.2]octan-2,6-dione (3), a so far elusive key intermediate in the Liu-Ralitsch total synthesis of (+)-norpatchoulenol ((+)-1a), is described. The preparation of 3 constitutes also a formal total synthesis of (±)-iso-norpatchoulenol ((±)-1b), since 3 is correlated to an intermediate in the Monti and co-workers synthesis of (±)-1b.
A new preparation of 1,3,3-trimethylbicyclo[2.2.2]octan-2,6-dione, a never isolated intermediate in a total synthesis of (+)-norpatchoulenol. Formal total synthesis of (±)-iso-norpatchoulenol / LA BELLA, Angela; Leonelli, Francesca; Ilse, De salve; Migneco, Luisa Maria; MARINI BETTOLO, Rinaldo. - In: HELVETICA CHIMICA ACTA. - ISSN 0018-019X. - STAMPA. - 87:8(2004), pp. 2120-2124. [10.1002/hlca.200490191]
A new preparation of 1,3,3-trimethylbicyclo[2.2.2]octan-2,6-dione, a never isolated intermediate in a total synthesis of (+)-norpatchoulenol. Formal total synthesis of (±)-iso-norpatchoulenol
LA BELLA, ANGELA;LEONELLI, Francesca;MIGNECO, Luisa Maria;MARINI BETTOLO, Rinaldo
2004
Abstract
A new preparation and the isolation and spectroscopic characterization of 1,3,3-trimethylbicyclo[2.2.2]octan-2,6-dione (3), a so far elusive key intermediate in the Liu-Ralitsch total synthesis of (+)-norpatchoulenol ((+)-1a), is described. The preparation of 3 constitutes also a formal total synthesis of (±)-iso-norpatchoulenol ((±)-1b), since 3 is correlated to an intermediate in the Monti and co-workers synthesis of (±)-1b.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
