New analogues (compounds 6, 7 and 9) of the mono- (8) and diphosphate (10) bioactive forms of the antiherpes drug acyclovir are described. In compound 6, the monophosphate moiety of 8 was replaced by an aminosulfonyloxy group, while in compounds 7 and 9, a phosphonoacetamidoxy and an O-ethyl phosphonoacetamidoxy moiety are, respectively present instead of the diphosphate one of 10. None of the compounds synthesized proved to possess an appreciable activity on herpes simplex virus (HSV) or human immunodeficiency virus (HIV). (C) 2000 Elsevier Science S.A. All rights reserved.
Synthesis and antiviral properties of novel analogues of monophosphate and diphosphate bioactive forms of acyclovir / Marco, Macchia; Antonelli, Guido; Simone, Bertini; Federico, Calvani; Valeria Di, Bussolo; Filippo, Minutolo; Ramon, Tesoro; Imperio, Tonetti; Turriziani, Ombretta. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 55:4(2000), pp. 322-327. [10.1016/s0014-827x(00)00046-x]
Synthesis and antiviral properties of novel analogues of monophosphate and diphosphate bioactive forms of acyclovir
ANTONELLI, Guido;TURRIZIANI, Ombretta
2000
Abstract
New analogues (compounds 6, 7 and 9) of the mono- (8) and diphosphate (10) bioactive forms of the antiherpes drug acyclovir are described. In compound 6, the monophosphate moiety of 8 was replaced by an aminosulfonyloxy group, while in compounds 7 and 9, a phosphonoacetamidoxy and an O-ethyl phosphonoacetamidoxy moiety are, respectively present instead of the diphosphate one of 10. None of the compounds synthesized proved to possess an appreciable activity on herpes simplex virus (HSV) or human immunodeficiency virus (HIV). (C) 2000 Elsevier Science S.A. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
