Thixotropic and thermally reversible gels have been prepared from doxorubicin—lecithin association products (DL12) by addition of salts to their aqueous solutions. The gel formation and the melting profiles have been followed by several spectroscopic techniques (1H NMR, UV-Vis, Circular Dichroism). The transition temperatures increase as the concentration of both the salt and the DL12 is increased, suggesting a progressive closer approach of the gel forming species. The process of the gel formation is cooperative and causes immobilization of the doxorubicin molecules of DL12.
Anthracycline Gels. II. Spectroscopic study on doxorubicin—lecithin association products / Giomini, Marcello; A. M., Giuliani; Giustini, Mauro; E., Trotta. - In: BIOPHYSICAL CHEMISTRY. - ISSN 0301-4622. - STAMPA. - 45:1(1992), pp. 31-40. [10.1016/0301-4622(92)87021-A]