The relative efficacy of a single 400 mg dose of albendazole or mebendazole in the treatment of nematode infections was assessed in 2- to 9-year-old children living in two different Bolivian rural communities. Both agents were equally very effective (100% cure rate) in treating ascariasis. Albendazole was clearly more active than mebendazole against hookworm infections, both in terms of egg reduction rate (92.8% vs. 62.4%) and cure rate (81.8% vs. 17.2%). As far as trichuriasis is concerned, albendazole produced a higher egg reduction rate than mebendazole (45.7% vs 15%), but a lower cure rate (33.3% vs 60%). Both drugs were well tolerated.
Comparative efficacy of a single 400 mg dose of albendazole or mebendazole in the treatment of nematode infections in children / Bartoloni, A; Guglielmetti, P; Cancrini, Gabriella; Gamboa, H; Roselli, M; Nicoletti, A; Paradisi, F.. - In: TROPICAL AND GEOGRAPHICAL MEDICINE. - ISSN 0041-3232. - STAMPA. - 45:3(1993), pp. 114-116.
Comparative efficacy of a single 400 mg dose of albendazole or mebendazole in the treatment of nematode infections in children.
CANCRINI, Gabriella;
1993
Abstract
The relative efficacy of a single 400 mg dose of albendazole or mebendazole in the treatment of nematode infections was assessed in 2- to 9-year-old children living in two different Bolivian rural communities. Both agents were equally very effective (100% cure rate) in treating ascariasis. Albendazole was clearly more active than mebendazole against hookworm infections, both in terms of egg reduction rate (92.8% vs. 62.4%) and cure rate (81.8% vs. 17.2%). As far as trichuriasis is concerned, albendazole produced a higher egg reduction rate than mebendazole (45.7% vs 15%), but a lower cure rate (33.3% vs 60%). Both drugs were well tolerated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
