The structure of the complex between DNA and polylysine is analyzed on the basis of conformational calculations and experimental findings and possible connections with the local structure of nucleohistones are discussed. A molecular model characterized by alternant peptide sequences of right-handed and left-handed α-helix-type conformations, winding along the narrow groove of DNA in the B-type form, is proposed. This model is stabilized by hydrophobic, electrostatic, and hydrogen-bond interactions between the ζ-amino groups and the phosphate residues of both the strands of DNA and by hydrogen bonds between the NH peptide groups and the bases of one strand of the double helix.
Conformational studies on deoxyribonucleic acid-polylysine complexes / DE SANTIS, Pasquale; R., Rizzo; Savino, Maria. - In: MACROMOLECULES. - ISSN 0024-9297. - STAMPA. - 6:4(1973), pp. 520-522. [10.1021/ma60034a012]
Conformational studies on deoxyribonucleic acid-polylysine complexes.
DE SANTIS, Pasquale;SAVINO, Maria
1973
Abstract
The structure of the complex between DNA and polylysine is analyzed on the basis of conformational calculations and experimental findings and possible connections with the local structure of nucleohistones are discussed. A molecular model characterized by alternant peptide sequences of right-handed and left-handed α-helix-type conformations, winding along the narrow groove of DNA in the B-type form, is proposed. This model is stabilized by hydrophobic, electrostatic, and hydrogen-bond interactions between the ζ-amino groups and the phosphate residues of both the strands of DNA and by hydrogen bonds between the NH peptide groups and the bases of one strand of the double helix.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
