Objective: To evaluate alfentanil, sufentanil, and the combination of both opioids in patients undergoing cardiac surgery. Design: Prospective, randomized study. Setting: University hospital. Participants: Patients undergoing coronary artery bypass graft (CABG) surgery (n 195), randomly assigned to 3 groups of 65 each. Interventions: Patients in group A received alfentanil, induction (15 g/kg) and maintenance (15 g/kg/hr); patients in group S received sufentanil, induction (1 g/kg) and maintenance (1 g/kg/h); and patients in group AS received alfentanil and sufentanil, induction with alfentanil (15 g/kg) and maintenance with sufentanil (1 g/ kg/hr). Measurements and Main Results: Hemodynamic data showed a reduction of all parameters at induction in the 3 groups (p < 0.05). Cardiac index decreased at induction in all groups (p < 0.05) but increased in groups S and AS toward baseline values at the end of surgery. The intubation time and length of stay in the intensive care unit were less in group AS (2.3 1.2 hours; p < 0.001 and 20 8 hours; p < 0.05), than in groups A (4.2 1.7 hours and 28 13 hours) and S (3.1 1.1 hours; p < 0.05 and 26 12 hours). Length of hospital stay and patients’ outcome were similar in the 3 groups. Conclusion: Although the differences among groups regarding extubation time, intensive care unit length of stay, and some hemodynamic data were statistically significant, the differences were clinically small. All 3 anesthetic protocols were shown to be safe and appropriate for patients undergoing elective coronary artery bypass graft surgery and early postoperative tracheal extubation.

Alfentanil and sufentanil in fast-track anesthesia for coronary artery bypass graft surgery / Tritapepe, Luigi; DI GIOVANNI, Claudio; Pizzuto, F; Cuscianna, E; Caretta, Q; Pietropaoli, Paolo; Voci, Paolo. - In: JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA. - ISSN 1053-0770. - 16:(2002), pp. 157-162. [10.1053/jcan.2002.31056]

Alfentanil and sufentanil in fast-track anesthesia for coronary artery bypass graft surgery.

TRITAPEPE, Luigi
;
DI GIOVANNI, Claudio;PIETROPAOLI, Paolo;VOCI, Paolo
2002

Abstract

Objective: To evaluate alfentanil, sufentanil, and the combination of both opioids in patients undergoing cardiac surgery. Design: Prospective, randomized study. Setting: University hospital. Participants: Patients undergoing coronary artery bypass graft (CABG) surgery (n 195), randomly assigned to 3 groups of 65 each. Interventions: Patients in group A received alfentanil, induction (15 g/kg) and maintenance (15 g/kg/hr); patients in group S received sufentanil, induction (1 g/kg) and maintenance (1 g/kg/h); and patients in group AS received alfentanil and sufentanil, induction with alfentanil (15 g/kg) and maintenance with sufentanil (1 g/ kg/hr). Measurements and Main Results: Hemodynamic data showed a reduction of all parameters at induction in the 3 groups (p < 0.05). Cardiac index decreased at induction in all groups (p < 0.05) but increased in groups S and AS toward baseline values at the end of surgery. The intubation time and length of stay in the intensive care unit were less in group AS (2.3 1.2 hours; p < 0.001 and 20 8 hours; p < 0.05), than in groups A (4.2 1.7 hours and 28 13 hours) and S (3.1 1.1 hours; p < 0.05 and 26 12 hours). Length of hospital stay and patients’ outcome were similar in the 3 groups. Conclusion: Although the differences among groups regarding extubation time, intensive care unit length of stay, and some hemodynamic data were statistically significant, the differences were clinically small. All 3 anesthetic protocols were shown to be safe and appropriate for patients undergoing elective coronary artery bypass graft surgery and early postoperative tracheal extubation.
2002
alfentanil, sufentanil, cardiac anesthesia
01 Pubblicazione su rivista::01l Trial clinico
Alfentanil and sufentanil in fast-track anesthesia for coronary artery bypass graft surgery / Tritapepe, Luigi; DI GIOVANNI, Claudio; Pizzuto, F; Cuscianna, E; Caretta, Q; Pietropaoli, Paolo; Voci, Paolo. - In: JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA. - ISSN 1053-0770. - 16:(2002), pp. 157-162. [10.1053/jcan.2002.31056]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/38818
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