Ultrasonic vocalization in rat pups as a marker of behavioral development: an investigation of the effects of drug influencing brain opioid system

Cuomo, Vincenzo; Cagiano, R; De Salvia Ma,; Restani, P; Galimberti, R; Racagni, G; Galli, Cl

doi:10.1016/0892-0362(88)90009-8

Early postnatal exposure to morphine significantly influenced the ultrasonic vocalization of rat pups removed from their nest. In particular, a significant decrease in the rate of calling, sound pressure level and range of frequency was found in morphine-treated animals; moreover, the duration of calls was significantly increased by morphine administration. Conversely, neither beta-casomorphins (beta CMS), which are opioid peptides derived from the enzymatic digestion of milk protein (beta-casein), nor an opioid antagonist, like naloxone, significantly affected ultrasonic emission. The results are discussed with particular reference to the role of the opioid system in separation distress-induced vocalization in young animals.

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Titolo:	Ultrasonic vocalization in rat pups as a marker of behavioral development: an investigation of the effects of drug influencing brain opioid system
Autori:	CUOMO, VINCENZO CAGIANO R DE SALVIA MA RESTANI P GALIMBERTI R RACAGNI G GALLI CL mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1988
Rivista:	NEUROTOXICOLOGY AND TERATOLOGY
Handle:	http://hdl.handle.net/11573/38814
Appartiene alla tipologia:	01a Articolo in rivista

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