Early postnatal exposure to morphine significantly influenced the ultrasonic vocalization of rat pups removed from their nest. In particular, a significant decrease in the rate of calling, sound pressure level and range of frequency was found in morphine-treated animals; moreover, the duration of calls was significantly increased by morphine administration. Conversely, neither beta-casomorphins (beta CMS), which are opioid peptides derived from the enzymatic digestion of milk protein (beta-casein), nor an opioid antagonist, like naloxone, significantly affected ultrasonic emission. The results are discussed with particular reference to the role of the opioid system in separation distress-induced vocalization in young animals.
Ultrasonic vocalization in rat pups as a marker of behavioral development: an investigation of the effects of drug influencing brain opioid system / Cuomo, Vincenzo; Cagiano, R; DE SALVIA, Ma; Restani, P; Galimberti, R; Racagni, G; Galli, Cl. - In: NEUROTOXICOLOGY AND TERATOLOGY. - ISSN 0892-0362. - STAMPA. - 10:(1988), pp. 465-469. [10.1016/0892-0362(88)90009-8]
Ultrasonic vocalization in rat pups as a marker of behavioral development: an investigation of the effects of drug influencing brain opioid system
CUOMO, VINCENZO;
1988
Abstract
Early postnatal exposure to morphine significantly influenced the ultrasonic vocalization of rat pups removed from their nest. In particular, a significant decrease in the rate of calling, sound pressure level and range of frequency was found in morphine-treated animals; moreover, the duration of calls was significantly increased by morphine administration. Conversely, neither beta-casomorphins (beta CMS), which are opioid peptides derived from the enzymatic digestion of milk protein (beta-casein), nor an opioid antagonist, like naloxone, significantly affected ultrasonic emission. The results are discussed with particular reference to the role of the opioid system in separation distress-induced vocalization in young animals.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.