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EnglishEarly postnatal exposure to morphine significantly influenced the ultrasonic vocalization of rat pups removed from their nest. In particular, a significant decrease in the rate of calling, sound pressure level and range of frequency was found in morphine-treated animals; moreover, the duration of calls was significantly increased by morphine administration. Conversely, neither beta-casomorphins (beta CMS), which are opioid peptides derived from the enzymatic digestion of milk protein (beta-casein), nor an opioid antagonist, like naloxone, significantly affected ultrasonic emission. The results are discussed with particular reference to the role of the opioid system in separation distress-induced vocalization in young animals.
Ultrasonic vocalization in rat pups as a marker of behavioral development: an investigation of the effects of drug influencing brain opioid system / Cuomo, Vincenzo; Cagiano, R; DE SALVIA, Ma; Restani, P; Galimberti, R; Racagni, G; Galli, Cl. - In: NEUROTOXICOLOGY AND TERATOLOGY. - ISSN 0892-0362. - STAMPA. - 10(1988), pp. 465-469. [10.1016/0892-0362(88)90009-8]
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| Titolo: | Ultrasonic vocalization in rat pups as a marker of behavioral development: an investigation of the effects of drug influencing brain opioid system | |
| Autori: | ||
| Data di pubblicazione: | 1988 | |
| Rivista: | ||
| Citazione: | Ultrasonic vocalization in rat pups as a marker of behavioral development: an investigation of the effects of drug influencing brain opioid system / Cuomo, Vincenzo; Cagiano, R; DE SALVIA, Ma; Restani, P; Galimberti, R; Racagni, G; Galli, Cl. - In: NEUROTOXICOLOGY AND TERATOLOGY. - ISSN 0892-0362. - STAMPA. - 10(1988), pp. 465-469. [10.1016/0892-0362(88)90009-8] | |
| Handle: | http://hdl.handle.net/11573/38814 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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