Early postnatal exposure to morphine significantly influenced the ultrasonic vocalization of rat pups removed from their nest. In particular, a significant decrease in the rate of calling, sound pressure level and range of frequency was found in morphine-treated animals; moreover, the duration of calls was significantly increased by morphine administration. Conversely, neither beta-casomorphins (beta CMS), which are opioid peptides derived from the enzymatic digestion of milk protein (beta-casein), nor an opioid antagonist, like naloxone, significantly affected ultrasonic emission. The results are discussed with particular reference to the role of the opioid system in separation distress-induced vocalization in young animals.
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|Titolo:||Ultrasonic vocalization in rat pups as a marker of behavioral development: an investigation of the effects of drug influencing brain opioid system|
|Data di pubblicazione:||1988|
|Appartiene alla tipologia:||01a Articolo in rivista|