The intracellular localization of hepatitis C virus structural proteins was analyzed by confocal immunofluorescence microscopy, cell fractionation, and immunoelectron microscopy in stably transfected cells that do not overexpress the viral proteins. The results strongly suggest that at steady state the structural proteins reside not only in the endoplasmic reticulum but also in the intermediate compartment and cis-Golgi complex region. By analogy with other viral systems, this finding raises the possibility that the intermediate compartment and cis-Golgi complex play a role in the assembly and budding of hepatitis C virus. (C) 2001 Academic Press.

Hepatitis C virus structural proteins reside in the endoplasmic reticulum as well as in the intermediate compartment/cis-Golgi complex region of stably transfected cells / G., Martire; A., Viola; L., Iodice; Lotti, Lavinia Vittoria; Gradini, Roberto; S., Bonatti. - In: VIROLOGY. - ISSN 0042-6822. - STAMPA. - 280:2(2001), pp. 176-182. [10.1006/viro.2000.0733]

Hepatitis C virus structural proteins reside in the endoplasmic reticulum as well as in the intermediate compartment/cis-Golgi complex region of stably transfected cells

LOTTI, Lavinia Vittoria;GRADINI, Roberto;
2001

Abstract

The intracellular localization of hepatitis C virus structural proteins was analyzed by confocal immunofluorescence microscopy, cell fractionation, and immunoelectron microscopy in stably transfected cells that do not overexpress the viral proteins. The results strongly suggest that at steady state the structural proteins reside not only in the endoplasmic reticulum but also in the intermediate compartment and cis-Golgi complex region. By analogy with other viral systems, this finding raises the possibility that the intermediate compartment and cis-Golgi complex play a role in the assembly and budding of hepatitis C virus. (C) 2001 Academic Press.
2001
01 Pubblicazione su rivista::01a Articolo in rivista
Hepatitis C virus structural proteins reside in the endoplasmic reticulum as well as in the intermediate compartment/cis-Golgi complex region of stably transfected cells / G., Martire; A., Viola; L., Iodice; Lotti, Lavinia Vittoria; Gradini, Roberto; S., Bonatti. - In: VIROLOGY. - ISSN 0042-6822. - STAMPA. - 280:2(2001), pp. 176-182. [10.1006/viro.2000.0733]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/387985
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