Goal-directed intraoperative therapy reduces morbidity and length of hospital stay in high-risk surgical patients.

National Institutes of Health Search termSearch database All DatabasesPubMedProteinNucleotideGSSESTStructureGenomeBioProjectBioSampleBioSystemsBooksConserved DomainsClonedbGaPdbVarEpigenomicsGeneGEO DataSetsGEO ProfilesHomoloGeneMeSHNCBI Web SiteNLM CatalogOMIAOMIMPMCPopSetProbeProtein ClustersPubChem BioAssayPubChem CompoundPubChem SubstancePubMed HealthSNPSRATaxonomyToolKitToolKitAllUniGeneUniSTS SearchAdvanced Help Result Filters Display Settings: Abstract Send to: Chest. 2007 Dec;132(6):1817-24. Epub 2007 Oct 9. Goal-directed intraoperative therapy reduces morbidity and length of hospital stay in high-risk surgical patients. Donati A, Loggi S, Preiser JC, Orsetti G, Münch C, Gabbanelli V, Pelaia P, Pietropaoli P. Source Department of Neuroscience, Anesthesia, and Intensive Care Unit, Marche Polytechnique University, Torrette di Ancona, Italy. donati.abele@tiscali.it Abstract BACKGROUND: Postoperative organ failures commonly occur after major abdominal surgery, increasing the utilization of resources and costs of care. Tissue hypoxia is a key trigger of organ dysfunction. A therapeutic strategy designed to detect and reverse tissue hypoxia, as diagnosed by an increase of oxygen extraction (O2ER) over a predefined threshold, could decrease the incidence of organ failures. The primary aim of this study was to compare the number of patients with postoperative organ failure and length of hospital stay between those randomized to conventional vs a protocolized strategy designed to maintain O2ER < 27%. METHODS: A prospective, randomized, controlled trial was performed in nine hospitals in Italy. One hundred thirty-five high-risk patients scheduled for major abdominal surgery were randomized in two groups. All patients were managed to achieve standard goals: mean arterial pressure > 80 mm Hg and urinary output > 0.5 mL/kg/h. The patients of the "protocol group" (group A) were also managed to keep O2ER < 27%. MEASUREMENTS AND MAIN RESULTS: In group A, fewer patients had at least one organ failure (n = 8, 11.8%) than in group B (n = 20, 29.8%) [p < 0.05], and the total number of organ failures was lower in group A than in group B (27 failures vs 9 failures, p < 0.001). Length of hospital stay was significantly lower in the protocol group than in the control group (11.3 +/- 3.8 days vs 13.4 +/- 6.1 days, p < 0.05). Hospital mortality was similar in both groups. CONCLUSIONS: Early treatment directed to maintain O2ER at < 27% reduces organ failures and hospital stay of high-risk surgical patients. Clinical trials.gov reference No. NCT00254150. Comment in Chest. 2008 Jul;134(1):215; author reply 216.