The synthesis of a new segmented polyurethane containing quaternary ammonium groups in the side-chain is reported. The quaternization was carried out both on the polymer dissolved in an organic solvent and on polymer films. Polymeric films quaternized by both techniques were heparinized. The amount of bonded heparin, determined by spectrophotometry, was remarkably higher than previously described. Polymer quaternized in solution bonded more heparin than that heparinized directly on film. In vitro evaluations of antithrombogenicity by activated partial thromboplastin time (APTT) carried out on the films confirmed these data. The polymers were also characterized by chemical, i.r., n.m.r., differential scanning calorimetry and viscometric techniques.

Synthesis and physico chemical characterization of a hydrophilic polyurethane able to bind ionically high amounts of heparin / Marconi, Valter; Martinelli, Andrea; Piozzi, Antonella; Zane, Daniela. - In: BIOMATERIALS. - ISSN 0142-9612. - STAMPA. - 13:(1992), pp. 432-438. [10.1016/0142-9612(92)90163-I]

Synthesis and physico chemical characterization of a hydrophilic polyurethane able to bind ionically high amounts of heparin

MARCONI, Valter;MARTINELLI, Andrea;PIOZZI, Antonella;ZANE, DANIELA
1992

Abstract

The synthesis of a new segmented polyurethane containing quaternary ammonium groups in the side-chain is reported. The quaternization was carried out both on the polymer dissolved in an organic solvent and on polymer films. Polymeric films quaternized by both techniques were heparinized. The amount of bonded heparin, determined by spectrophotometry, was remarkably higher than previously described. Polymer quaternized in solution bonded more heparin than that heparinized directly on film. In vitro evaluations of antithrombogenicity by activated partial thromboplastin time (APTT) carried out on the films confirmed these data. The polymers were also characterized by chemical, i.r., n.m.r., differential scanning calorimetry and viscometric techniques.
1992
polyurethanes; heparinization
01 Pubblicazione su rivista::01a Articolo in rivista
Synthesis and physico chemical characterization of a hydrophilic polyurethane able to bind ionically high amounts of heparin / Marconi, Valter; Martinelli, Andrea; Piozzi, Antonella; Zane, Daniela. - In: BIOMATERIALS. - ISSN 0142-9612. - STAMPA. - 13:(1992), pp. 432-438. [10.1016/0142-9612(92)90163-I]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/387643
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