Polymers find widespread applications in the medical device field. However, they can be easily colonized by bacteria and fungi, thus frequently causing severe infections in patients. Recently, antibiotic-treated polymers have been proved to reduce bacterial colonization. However, a moderate risk of emergence of multidrug-resistant pathogens has been point out due to the low antibiotic systemic levels reached in patients after a prolonged time of implant of antibiotic-treated devices. In order to reduce this risk, we developed antibacterial polyurethanes containing a combination of antimicrobial drugs having different mechanisms of action: i) ions of transition metals (Ag+, Cu2+ and Fe3+), known for their broad spectrum of antimicrobial activity against bacterial, fungal and viral agents, together with their no cross-resistance with antibiotics1 and ii) the broad-spectrum antibiotic ciprofloxacin (CPF).
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|Titolo:||Antimicrobial biomaterials based on transition metal-containing polyurethanes and ciprofloxacin loading|
|Data di pubblicazione:||2005|
|Appartiene alla tipologia:||04a Atto di comunicazione a congresso|