The synthesis of new segmented polyurethanes containing as chain extender N-hexadecyl-2,2-bis(hydroxymethyl)propionamide (alone or with 1,4-butanediol at different mole ratios) is described. The degree of hydrophobicity and the glass transition temperatures T(g) were found to be proportional to the alkyl chain content of the polymers. Also the amount of bonded albumin is proportional to the alkyl group content of the polymer, and platelet adhesion is remarkably lower for the 100% alkylated polymer (PEUHDA) than for the standard non-alkylated polyurethane (PEU). This behaviour was confirmed by SEM evaluation, showing a much lower degree of activation of platelets on albuminized PEUHDA films. It was not possible to ascertain with sufficient reliability a different behaviour, with respect to platelet adhesion, of the polymers containing alkyl chains in the range 9 divided-by 50 mol%, due to the relatively high error of the evaluation systems.

SYNTHESIS AND CHARACTERIZATION OF NEW HYDROPHOBIC POLYURETHANES FOR BIOMEDICAL APPLICATIONS / Marconi, Valter; Martinelli, Andrea; Piozzi, Antonella; Zane, Daniela. - In: MACROMOLECULAR CHEMISTRY AND PHYSICS. - ISSN 1022-1352. - STAMPA. - 195:3(1994), pp. 875-888. [10.1002/macp.1994.021950306]

SYNTHESIS AND CHARACTERIZATION OF NEW HYDROPHOBIC POLYURETHANES FOR BIOMEDICAL APPLICATIONS

MARCONI, Valter;MARTINELLI, Andrea;PIOZZI, Antonella;ZANE, DANIELA
1994

Abstract

The synthesis of new segmented polyurethanes containing as chain extender N-hexadecyl-2,2-bis(hydroxymethyl)propionamide (alone or with 1,4-butanediol at different mole ratios) is described. The degree of hydrophobicity and the glass transition temperatures T(g) were found to be proportional to the alkyl chain content of the polymers. Also the amount of bonded albumin is proportional to the alkyl group content of the polymer, and platelet adhesion is remarkably lower for the 100% alkylated polymer (PEUHDA) than for the standard non-alkylated polyurethane (PEU). This behaviour was confirmed by SEM evaluation, showing a much lower degree of activation of platelets on albuminized PEUHDA films. It was not possible to ascertain with sufficient reliability a different behaviour, with respect to platelet adhesion, of the polymers containing alkyl chains in the range 9 divided-by 50 mol%, due to the relatively high error of the evaluation systems.
1994
albumin; hydrophobic polyurethane; platelet adhesion; segmented polyurethanes
01 Pubblicazione su rivista::01a Articolo in rivista
SYNTHESIS AND CHARACTERIZATION OF NEW HYDROPHOBIC POLYURETHANES FOR BIOMEDICAL APPLICATIONS / Marconi, Valter; Martinelli, Andrea; Piozzi, Antonella; Zane, Daniela. - In: MACROMOLECULAR CHEMISTRY AND PHYSICS. - ISSN 1022-1352. - STAMPA. - 195:3(1994), pp. 875-888. [10.1002/macp.1994.021950306]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/387465
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 29
social impact