Aim: To assess the positive predictive value (PPV) of CTC in the clinical routine of a dedicated referral centre. Material and methods: All consecutive patients referred for CTC between May 2009 and May 2010 were considered for inclusion in this study. All the patients who, following the diagnosis of a > 6 mm polyp or mass at CTC, underwent a post-CTC colonoscopy within eight weeks from diagnosis were included. Per patient PPV for lesions, adenomas and advanced neoplasia was calculated. Chi-square test was used for statistical comparison, and a p value <0.05 was considered to be statistically significant. Results: 516 patients were included in the study. Of them, 76 (14%) patients had at least one lesion >= 6 mm on CTC. Overall, 59 (11%) patients were diagnosed at CTC with at least one polyp, 12 (2%) with a flat lesions, and 5 (1%) with a mass. Per-patient PPVs for any lesion >6 mm, neoplasia, and advanced neoplasia were 96% (95% CI: 92-100%), 68.4% (95% CI: 58-79%), and 30% (95% CI: 20-41%), respectively. PPV for neoplasia and advanced neoplasia was substantially higher for > 10 mm lesions. Conclusion: In dedicated centers, CTC appears to be a highly specific procedure, characterized by a very low rate of false-positive results for > 6 mm lesions. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

High positive predictive value of CT colonography in a referral centre / Iafrate, Francesco; C., Hassan; Ciolina, Maria; Lamazza, Antonietta; P., Baldassari; A., Pichi; A., Zullo; Stagnitti, Andrea; M., Iannitti; Rengo, Marco; Laghi, Andrea. - In: EUROPEAN JOURNAL OF RADIOLOGY. - ISSN 0720-048X. - STAMPA. - 80:3(2011), pp. e289-e292. [10.1016/j.ejrad.2010.12.080]

High positive predictive value of CT colonography in a referral centre

CIOLINA, MARIA;LAMAZZA, Antonietta;STAGNITTI, ANDREA;RENGO, MARCO;LAGHI, ANDREA
2011

Abstract

Aim: To assess the positive predictive value (PPV) of CTC in the clinical routine of a dedicated referral centre. Material and methods: All consecutive patients referred for CTC between May 2009 and May 2010 were considered for inclusion in this study. All the patients who, following the diagnosis of a > 6 mm polyp or mass at CTC, underwent a post-CTC colonoscopy within eight weeks from diagnosis were included. Per patient PPV for lesions, adenomas and advanced neoplasia was calculated. Chi-square test was used for statistical comparison, and a p value <0.05 was considered to be statistically significant. Results: 516 patients were included in the study. Of them, 76 (14%) patients had at least one lesion >= 6 mm on CTC. Overall, 59 (11%) patients were diagnosed at CTC with at least one polyp, 12 (2%) with a flat lesions, and 5 (1%) with a mass. Per-patient PPVs for any lesion >6 mm, neoplasia, and advanced neoplasia were 96% (95% CI: 92-100%), 68.4% (95% CI: 58-79%), and 30% (95% CI: 20-41%), respectively. PPV for neoplasia and advanced neoplasia was substantially higher for > 10 mm lesions. Conclusion: In dedicated centers, CTC appears to be a highly specific procedure, characterized by a very low rate of false-positive results for > 6 mm lesions. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
2011
ct colonography; positive predictive value; colonic adenomas; virtual colonoscopy; colonic cancer
01 Pubblicazione su rivista::01a Articolo in rivista
High positive predictive value of CT colonography in a referral centre / Iafrate, Francesco; C., Hassan; Ciolina, Maria; Lamazza, Antonietta; P., Baldassari; A., Pichi; A., Zullo; Stagnitti, Andrea; M., Iannitti; Rengo, Marco; Laghi, Andrea. - In: EUROPEAN JOURNAL OF RADIOLOGY. - ISSN 0720-048X. - STAMPA. - 80:3(2011), pp. e289-e292. [10.1016/j.ejrad.2010.12.080]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/386990
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