Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. Its function is impaired in patients with hypertension, with reduced vasodilation, increased vascular tone associated with a proinflammatory and prothrombotic state. Low-grade inflammation localized in vascular tissue is therefore recognized as an important contributor to the pathophysiology of hypertension, to the initiation and progression of atherosclerosis as well as to the development of cardiovascular diseases. © 2011 Carmine Savoia et al.
Vascular inflammation and endothelial dysfunction in experimental hypertension / Savoia, Carmine; Lidia, Sada; Luigi, Zezza; Lorenzo, Pucci; Francesco Maria, Lauri; Alberto, Befani; Alonzo, Alessandro; Volpe, Massimo. - In: INTERNATIONAL JOURNAL OF HYPERTENSION. - ISSN 2090-0384. - 2011:(2011), pp. 1-8. [10.4061/2011/281240]
Vascular inflammation and endothelial dysfunction in experimental hypertension
SAVOIA, Carmine;ALONZO, ALESSANDRO;VOLPE, Massimo
2011
Abstract
Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. Its function is impaired in patients with hypertension, with reduced vasodilation, increased vascular tone associated with a proinflammatory and prothrombotic state. Low-grade inflammation localized in vascular tissue is therefore recognized as an important contributor to the pathophysiology of hypertension, to the initiation and progression of atherosclerosis as well as to the development of cardiovascular diseases. © 2011 Carmine Savoia et al.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
