A superoxide dismutase biosensor was used to determine the antioxidant properties of scavenger molecules and the antiradical activity of healthy and diseased human kidney tissues; this biosensor is based on the use of the enzyme superoxide dismutase (SOD), which is physically entrapped in a kappa-carrageenan gel membrane, and of a transducer consisting of an amperometric hydrogen peroxide electrode. Several compounds with scavenging properties were tested, including some commercial drugs. (C) 2000 Elsevier Science B.V. All rights reserved.
New biosensor for superoxide radical used to evidence molecules of biomedical and pharmaceutical interest having radical scavenging properties / Campanella, Luigi; Favero, Gabriele; L., Persi; Tomassetti, Mauro. - In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - ISSN 0731-7085. - 23:1(2000), pp. 69-76. (Intervento presentato al convegno 8th International Meeting on Recent Developments in Pharmaceutical Analysis (RDPA 99) tenutosi a ROME, ITALY nel JUN 29-JUL 03, 1999) [10.1016/s0731-7085(00)00276-4].
New biosensor for superoxide radical used to evidence molecules of biomedical and pharmaceutical interest having radical scavenging properties
CAMPANELLA, Luigi;FAVERO, Gabriele;TOMASSETTI, Mauro
2000
Abstract
A superoxide dismutase biosensor was used to determine the antioxidant properties of scavenger molecules and the antiradical activity of healthy and diseased human kidney tissues; this biosensor is based on the use of the enzyme superoxide dismutase (SOD), which is physically entrapped in a kappa-carrageenan gel membrane, and of a transducer consisting of an amperometric hydrogen peroxide electrode. Several compounds with scavenging properties were tested, including some commercial drugs. (C) 2000 Elsevier Science B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.