Natural substances such as pelletierine and its analogues have been prepared in up to 97% ee and good yield by a protective-group-free, biomimetic approach. Usage of benzonitrile or acetonitrile as solvents effectively prevents product racemization.
Biomimetic Organocatalytic Asymmetric Synthesis of 2-Substituted Piperidine-Type Alkaloids and Their Analogues / Mattia R., Monaco; Renzi, Polyssena; SCARPINO SCHIETROMA, DANIELE MARIA; Bella, Marco. - In: ORGANIC LETTERS. - ISSN 1523-7060. - STAMPA. - 13:17(2011), pp. 4546-4549. [10.1021/ol2017406]
Biomimetic Organocatalytic Asymmetric Synthesis of 2-Substituted Piperidine-Type Alkaloids and Their Analogues
RENZI, POLYSSENA;SCARPINO SCHIETROMA, DANIELE MARIA;BELLA, Marco
2011
Abstract
Natural substances such as pelletierine and its analogues have been prepared in up to 97% ee and good yield by a protective-group-free, biomimetic approach. Usage of benzonitrile or acetonitrile as solvents effectively prevents product racemization.File allegati a questo prodotto
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