The synthesis and characterization of poly(DL-proline) are reported in relation with its predicted property of forming ion channels across membranes. The analysis of the conductance induced in synthetic bilayer membranes doped with poly(DL-proline) shows ionic permeoselectivity and the characteristic time course of fluctuations of ion channels, according to the similarity with the active structure of gramicidin A in membranes during the ion passage. An alternative mechanism of ion transport across bilayer membranes is also advanced.
Poly(DL-proline), a synthetic polypeptide behaving as an ion channel across bilayer membranes / P., De Santis; A., Palleschi; M., Savino; Scipioni, Anita; B., Sesta; A., Verdini. - In: BIOPHYSICAL CHEMISTRY. - ISSN 0301-4622. - STAMPA. - 21:(1985), pp. 211-215. [10.1016/0301-4622(85)80008-9]
Poly(DL-proline), a synthetic polypeptide behaving as an ion channel across bilayer membranes.
SCIPIONI, Anita;
1985
Abstract
The synthesis and characterization of poly(DL-proline) are reported in relation with its predicted property of forming ion channels across membranes. The analysis of the conductance induced in synthetic bilayer membranes doped with poly(DL-proline) shows ionic permeoselectivity and the characteristic time course of fluctuations of ion channels, according to the similarity with the active structure of gramicidin A in membranes during the ion passage. An alternative mechanism of ion transport across bilayer membranes is also advanced.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
