Purpose: to assess the safety and efficacy of fractionated stereotactic radiotherapy (FSRT) for large skull base meningiomas. Methods and Materials: Fifty-two patients with large skull base meningiomas aged 34-74 years (median age 56 years) were treated with FSRT between June 2004 and August 2009. All patients received FSRT for residual or progressive meningiomas more than 4 centimeters in greatest dimension. The median GTV was 35.4 cm(3) (range 24.1-94.9 cm(3)), and the median PTV was 47.6 cm(3) (range 33.5-142.7 cm(3)). Treatment volumes were achieved with 5-8 noncoplanar beams shaped using a micromultileaf collimator (MLC). Treatment was delivered in 30 daily fractions over 6 weeks to a total dose of 50 Gy using 6 MV photons. Outcome was assessed prospectively. Results: At a median follow-up of 42 months (range 9-72 months) the 3-year and 5-year progression-free survival (PFS) rates were 96% and 93%, respectively, and survival was 100%. Three patients required further debulking surgery for progressive disease. Hypopituitarism was the most commonly reported late complication, with a new hormone pituitary deficit occurring in 10 (19%) of patients. Clinically significant late neurological toxicity was observed in 3 (5.5%) patients consisting of worsening of pre-existing cranial deficits. Conclusion: FSRT as a high-precision technique of localized RT is suitable for the treatment of large skull base meningiomas. The local control is comparable to that reported following conventional external beam RT. Longer follow-up is required to assess long term efficacy and toxicity, particularly in terms of potential reduction of treatment-related late toxicity.

Fractionated stereotactic conformal radiotherapy for large benign skull base meningiomas / Giuseppe, Minniti; Enrico, Clarke; Luigi, Cavallo; Osti, Mattia Falchetto; Esposito, Vincenzo; Gianpaolo, Cantore; Paolo, Cappabianca; MAURIZI ENRICI, Riccardo. - In: RADIATION ONCOLOGY. - ISSN 1748-717X. - STAMPA. - 6:1(2011), pp. 1-7. [10.1186/1748-717x-6-36]

Fractionated stereotactic conformal radiotherapy for large benign skull base meningiomas

OSTI, Mattia Falchetto;ESPOSITO, Vincenzo;MAURIZI ENRICI, Riccardo;Giuseppe Minniti
2011

Abstract

Purpose: to assess the safety and efficacy of fractionated stereotactic radiotherapy (FSRT) for large skull base meningiomas. Methods and Materials: Fifty-two patients with large skull base meningiomas aged 34-74 years (median age 56 years) were treated with FSRT between June 2004 and August 2009. All patients received FSRT for residual or progressive meningiomas more than 4 centimeters in greatest dimension. The median GTV was 35.4 cm(3) (range 24.1-94.9 cm(3)), and the median PTV was 47.6 cm(3) (range 33.5-142.7 cm(3)). Treatment volumes were achieved with 5-8 noncoplanar beams shaped using a micromultileaf collimator (MLC). Treatment was delivered in 30 daily fractions over 6 weeks to a total dose of 50 Gy using 6 MV photons. Outcome was assessed prospectively. Results: At a median follow-up of 42 months (range 9-72 months) the 3-year and 5-year progression-free survival (PFS) rates were 96% and 93%, respectively, and survival was 100%. Three patients required further debulking surgery for progressive disease. Hypopituitarism was the most commonly reported late complication, with a new hormone pituitary deficit occurring in 10 (19%) of patients. Clinically significant late neurological toxicity was observed in 3 (5.5%) patients consisting of worsening of pre-existing cranial deficits. Conclusion: FSRT as a high-precision technique of localized RT is suitable for the treatment of large skull base meningiomas. The local control is comparable to that reported following conventional external beam RT. Longer follow-up is required to assess long term efficacy and toxicity, particularly in terms of potential reduction of treatment-related late toxicity.
2011
01 Pubblicazione su rivista::01a Articolo in rivista
Fractionated stereotactic conformal radiotherapy for large benign skull base meningiomas / Giuseppe, Minniti; Enrico, Clarke; Luigi, Cavallo; Osti, Mattia Falchetto; Esposito, Vincenzo; Gianpaolo, Cantore; Paolo, Cappabianca; MAURIZI ENRICI, Riccardo. - In: RADIATION ONCOLOGY. - ISSN 1748-717X. - STAMPA. - 6:1(2011), pp. 1-7. [10.1186/1748-717x-6-36]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/385136
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