A study developing enantiomeric separations by metal chelate additives to the mobile phase in reversed-phase liquid chromatography is reported. In particular the use of Cu(II) complexes of L-prolinamide (L-ProNH2) and L-valinamide (L-ValNH2) is examined and discussed. Interestingly, for a series of DNS-amino acids these selectors show higher enantioselectivity than that obtained with the corresponding nonderivatized amino acid–Cu(II) complexes
Enantiomeric resolution of DNS.amino acids by ligand exchange chromatography: Comparison of different chiral amino acid amides as additives to the mobile phase / Girelli, Anna Maria; M., Sinibaldi. - In: CHIRALITY. - ISSN 0899-0042. - STAMPA. - 2:(1990), pp. 190-193. [10.1002/chir.530020311]
Enantiomeric resolution of DNS.amino acids by ligand exchange chromatography: Comparison of different chiral amino acid amides as additives to the mobile phase
GIRELLI, Anna Maria;
1990
Abstract
A study developing enantiomeric separations by metal chelate additives to the mobile phase in reversed-phase liquid chromatography is reported. In particular the use of Cu(II) complexes of L-prolinamide (L-ProNH2) and L-valinamide (L-ValNH2) is examined and discussed. Interestingly, for a series of DNS-amino acids these selectors show higher enantioselectivity than that obtained with the corresponding nonderivatized amino acid–Cu(II) complexesI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
