H.E.L.P. LDL-apheresis clinical experience in ItalyStefanutti Claudia, Shafii Mahnaz, Di Giacomo Serafina, Morozzi Claudia, Mazzilli Sara and the Italian Multicenter Study on Low-Density-Lipoprotein -Apheresis Working GroupExtracorporeal Therapeutic Techniques Unit - Immunohematology and Transfusion MedicineDepartment of Molecular Medicine - University of Rome ‘La Sapienza’, ‘Umberto I’ Hospital 155, V.le del Policlinico Rome I-00161 EU The clinical benefits of LDL-apheresis (LDL_a) have been demonstrated in numerous studies: the H.E.L.P. LDL-Apheresis Multicenter Study, the LDL-Apheresis Atherosclerosis Regression Study (LAARS), the German Multicenter LDL-Apheresis Trial, and the Familial Hypercholesterolemia (FH) Regression Study. The use, efficacy and safety of the heparin-induced extra-corporeal LDL-precipitation (H.E.L.P.®)- LDL –apheresis (H.E.L.P.-LDL_a) for the long-term management of patients with severe dyslipidemia has been studied in a single center (Rome, “La Sapienza” University) open retrospective survey. The data from 22 patients were evaluated accounting for 1437 H.E.L.P. LDL_a procedures. The Plasmat™ Futura System is the device for H.E.L.P.-LDL_a. used selectively to remove apolipoprotein B100-containing-lipoproteins in patients with severe dyslipidemia in our center. Regular H.E.L.P. LDL_a treatment was administered weekly or biweekly in Homozygous and Heterozygous FH patients. H.E.L.P. LDL_a treatment was beneficial and safe in patients with refractory hypercholesterolemia genetically determined, and coronary artery disease. The increasing use of H.E.L.P. LDL_a in Italy was recently reported also by the coordination (Rome) of the Italian Multicenter Study on LDL-apheresis Working Group (unpublished data). Among 101 patients submitted to LDL_a in 18 Italian centers, 41 have been treated with H.E.L.P. LDL_a.
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|Titolo:||H.E.L.P. LDL-apheresis clinical experience in Italy|
|Data di pubblicazione:||2011|
|Appartiene alla tipologia:||04d Abstract in atti di convegno|