Background: Intra-peritoneal adipose tissue is recognized as a predictor of metabolic syndrome and may contribute to the risk for cardiovascular disease by the production of adipocytokines, including adiponectin. Nevertheless, there is no knowledge on whether other visceral depots of adipose tissue, including the epicardial fat, have any metabolically active role, including production of adiponectin. Aim of the study: We sought to evaluate adiponectin protein expression in epicardial adipose tissue in vivo both in patients with severe coronary artery disease (CAD) and in subjects without CAD. Methods: Twenty-two patients were enrolled for the study. We selected 16 patients who underwent elective coronary artery bypass graft surgery for critical CAD, 5 who underwent surgery for valve replacement and I for correction of an interatrial defect. Epicardial adipose tissue biopsy samples were obtained before the initiation of cardiopulmonary bypass. Adiponectin protein level in epicardial adipose tissue was evaluated by Western blotting. Results: Adiponectin protein value, expressed as adiponectin/actin ratio, in epicardial adipose tissue was significantly lower in patients with severe CAD than in those without CAD (1.42 +/- 0.77 vs 2.36 +/- 0.84 p = 0.02, 95% CI 0.64-1.74). Conclusions: This study showed for the first time that human epicardial adipose tissue expresses adiponectin. Adiponectin expression is significantly lower in epicardial fat isolated from patients with CAD. (c) 2005 Elsevier Ltd. All rights reserved.

Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease / G., Iacobellis; D., Pistilli; M., Gucciardo; Leonetti, Frida; Miraldi, Fabio; G., Brancaccio; Gallo, Pietro; DI GIOIA, Cira Rosaria Tiziana. - In: CYTOKINE. - ISSN 1043-4666. - STAMPA. - 29:6(2005), pp. 251-255. [10.1016/j.cyto.2004.11.002]

Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease

LEONETTI, Frida;MIRALDI, Fabio;GALLO, Pietro;DI GIOIA, Cira Rosaria Tiziana
2005

Abstract

Background: Intra-peritoneal adipose tissue is recognized as a predictor of metabolic syndrome and may contribute to the risk for cardiovascular disease by the production of adipocytokines, including adiponectin. Nevertheless, there is no knowledge on whether other visceral depots of adipose tissue, including the epicardial fat, have any metabolically active role, including production of adiponectin. Aim of the study: We sought to evaluate adiponectin protein expression in epicardial adipose tissue in vivo both in patients with severe coronary artery disease (CAD) and in subjects without CAD. Methods: Twenty-two patients were enrolled for the study. We selected 16 patients who underwent elective coronary artery bypass graft surgery for critical CAD, 5 who underwent surgery for valve replacement and I for correction of an interatrial defect. Epicardial adipose tissue biopsy samples were obtained before the initiation of cardiopulmonary bypass. Adiponectin protein level in epicardial adipose tissue was evaluated by Western blotting. Results: Adiponectin protein value, expressed as adiponectin/actin ratio, in epicardial adipose tissue was significantly lower in patients with severe CAD than in those without CAD (1.42 +/- 0.77 vs 2.36 +/- 0.84 p = 0.02, 95% CI 0.64-1.74). Conclusions: This study showed for the first time that human epicardial adipose tissue expresses adiponectin. Adiponectin expression is significantly lower in epicardial fat isolated from patients with CAD. (c) 2005 Elsevier Ltd. All rights reserved.
2005
coronary artery disease; adiponectin; epicardial adipose tissue
01 Pubblicazione su rivista::01a Articolo in rivista
Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease / G., Iacobellis; D., Pistilli; M., Gucciardo; Leonetti, Frida; Miraldi, Fabio; G., Brancaccio; Gallo, Pietro; DI GIOIA, Cira Rosaria Tiziana. - In: CYTOKINE. - ISSN 1043-4666. - STAMPA. - 29:6(2005), pp. 251-255. [10.1016/j.cyto.2004.11.002]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/384548
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 120
  • Scopus 389
  • ???jsp.display-item.citation.isi??? 367
social impact