We investigated the presence of human papillomaviruses (HPVs) types 16 and 18 DNA in formalin-fixed, paraffin-embedded tissues from the urinary bladder (46 transitional carcinomas and 10 non-neoplastic normal urinary samples) to find a possible role for HPV types in urinary tract cancerogenesis. The analysis was performed using polymerase chain reaction followed by filter hybridization with oligonucleotide-specific probes. The HPV16 and/or HPV18 genomes were detected in 23 of 46 (50%) bladder carcinomas and in none of 10 (0%) non-neoplastic urinary samples. These results suggest that HPV16 and 18 may carry a risk for the development of malignancy in the urinary tract as it occurs in the anogenital regions.

High frequency of human papillomavirus detection in urinary bladder cancer / Agliano', Anna Maria; Gradilone, Angela; Gazzaniga, Paola; M., Napolitano; R., Vercillo; L., Albonici; Naso, Giuseppe; V., Manzari; Frati, Luigi; A., Vecchione. - In: UROLOGIA INTERNATIONALIS. - ISSN 0042-1138. - STAMPA. - 53(1994), pp. 125-129. [10.1159/000282652]

High frequency of human papillomavirus detection in urinary bladder cancer

AGLIANO', Anna Maria;GRADILONE, Angela;GAZZANIGA, PAOLA;NASO, Giuseppe;FRATI, Luigi;
1994

Abstract

We investigated the presence of human papillomaviruses (HPVs) types 16 and 18 DNA in formalin-fixed, paraffin-embedded tissues from the urinary bladder (46 transitional carcinomas and 10 non-neoplastic normal urinary samples) to find a possible role for HPV types in urinary tract cancerogenesis. The analysis was performed using polymerase chain reaction followed by filter hybridization with oligonucleotide-specific probes. The HPV16 and/or HPV18 genomes were detected in 23 of 46 (50%) bladder carcinomas and in none of 10 (0%) non-neoplastic urinary samples. These results suggest that HPV16 and 18 may carry a risk for the development of malignancy in the urinary tract as it occurs in the anogenital regions.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/383747
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