From February 1987 to December 1988, 34 patients with histologically confirmed advanced colorectal carcinoma were entered in a phase II trial with 5-fluorouracil (5-FU) and folinic acid, for evaluation of treatment effectiveness and toxicity. Our data confirmed that the association 5-FU and folates represents an effective and moderately tolerated palliative treatment, with diarrhea being the only dose-limiting toxicity.
EFFICACY AND TOXICITY OF 5-FLUOROURACIL AND FOLATES IN ADVANCED COLON CANCER / Cortesi, Enrico; A. M., Aschelter; N., Gioacchini; A., Pellegrini; Frati, Luigi; C., Ficorella; N., Mazzei; Marchetti, Paolo. - In: JOURNAL OF CHEMOTHERAPY. - ISSN 1120-009X. - STAMPA. - 2:1(1990), pp. 47-50. (Intervento presentato al convegno WORKSHOP ON NEW FRONTIERS IN MEDICAL ONCOLOGY : MODULATION OF FLUOROPYRIMIDINES BY FOLATES tenutosi a ERICE, ITALY nel MAR 20-23, 1989).
EFFICACY AND TOXICITY OF 5-FLUOROURACIL AND FOLATES IN ADVANCED COLON CANCER
CORTESI, Enrico;FRATI, Luigi;MARCHETTI, PAOLO
1990
Abstract
From February 1987 to December 1988, 34 patients with histologically confirmed advanced colorectal carcinoma were entered in a phase II trial with 5-fluorouracil (5-FU) and folinic acid, for evaluation of treatment effectiveness and toxicity. Our data confirmed that the association 5-FU and folates represents an effective and moderately tolerated palliative treatment, with diarrhea being the only dose-limiting toxicity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
