C/EBP beta is considered a key element of interleukin-6 (IL-6) signalling as well as an important transcriptional regulator of the IL-6 gene itself. We describe here how mice lacking C/EBP beta develop a pathology similar to mice overexpressing IL-6 and nearly identical to multicentric Castleman's disease in human patients, with marked splenomegaly, peripheral lymphadenopathy and enhanced haemopoiesis. Humoral, innate and cellular immunity are also profoundly distorted, as shown by the defective activation of splenic macrophages, the strong impairement of IL-12 production, the increased susceptibility to Candida albicans infection and the altered T-helper function. Our data show that C/EBP beta is crucial for the correct functional regulation and homeostatic control of haemopoietic and lymphoid compartments.

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice / Screpanti, Isabella; L., Romani; P., Musiani; Modesti, Andrea; E., Fattori; D., Lazzaro; C., Sellitto; Scarpa, Susanna; Bellavia, Diana; G., Lattanzio; F., Bistoni; Frati, Luigi; R., Cortese; Gulino, Alberto; G., Ciliberto; F., Costantini; V., Poli. - In: EMBO JOURNAL. - ISSN 0261-4189. - STAMPA. - 14:(1995), pp. 1932-1941.

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice

SCREPANTI, Isabella;MODESTI, Andrea;SCARPA, Susanna;BELLAVIA, Diana;FRATI, Luigi;GULINO, Alberto;
1995

Abstract

C/EBP beta is considered a key element of interleukin-6 (IL-6) signalling as well as an important transcriptional regulator of the IL-6 gene itself. We describe here how mice lacking C/EBP beta develop a pathology similar to mice overexpressing IL-6 and nearly identical to multicentric Castleman's disease in human patients, with marked splenomegaly, peripheral lymphadenopathy and enhanced haemopoiesis. Humoral, innate and cellular immunity are also profoundly distorted, as shown by the defective activation of splenic macrophages, the strong impairement of IL-12 production, the increased susceptibility to Candida albicans infection and the altered T-helper function. Our data show that C/EBP beta is crucial for the correct functional regulation and homeostatic control of haemopoietic and lymphoid compartments.
1995
Castelman's disease; C/EBP; IL-6; gene targeting; T-helper
01 Pubblicazione su rivista::01a Articolo in rivista
Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice / Screpanti, Isabella; L., Romani; P., Musiani; Modesti, Andrea; E., Fattori; D., Lazzaro; C., Sellitto; Scarpa, Susanna; Bellavia, Diana; G., Lattanzio; F., Bistoni; Frati, Luigi; R., Cortese; Gulino, Alberto; G., Ciliberto; F., Costantini; V., Poli. - In: EMBO JOURNAL. - ISSN 0261-4189. - STAMPA. - 14:(1995), pp. 1932-1941.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/383327
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