Dilated cardiomyopathy is characterized by an increase in myocardial mass. In order to study the functional significance of myocellular hypertrophy in dilated cardiomyopathy, 40 left ventricular endomyocardial biopsies were investigated, by comparing morphometrical data with functional indexes. The extent of myofibril volume fraction was directly associated with a better functional condition, as measured by ejection fraction (p < 0.01) and cardiac index (p < 0.05). Patients with oversize nuclei (nuclear area being > or = 70 microns 2) had a worse functional status (p < 0.05), as determined by ejection fraction and cardiac index. Finally, the extent of interstitial fibrosis was directly correlated to mean right atrial pressure (p < 0.01), right ventricular end-diastolic pressure (p < 0.02) and mean pulmonary artery pressure (p < 0.02). In conclusion, a worse functional status correlates with a reduced myofibril volume fraction and an oversize nuclear area, as in hypertrophic cells undergoing regressive changes.

Functional significance of myocellular hypertrophy in dilated cardiomyopathy: histomorphometric analysis on 40 endomyocardial biopsies / Gallo, Pietro; Bernucci, P.; D'Amati, Giulia; Cianfrocca, C.; Pelliccia, F.; Marino, Benedetto. - In: THE AMERICAN JOURNAL OF CARDIOVASCULAR PATHOLOGY. - ISSN 0887-8005. - STAMPA. - 5:1(1995), pp. 11-18.

Functional significance of myocellular hypertrophy in dilated cardiomyopathy: histomorphometric analysis on 40 endomyocardial biopsies.

GALLO, Pietro;D'AMATI, Giulia;F. Pelliccia;MARINO, Benedetto
1995

Abstract

Dilated cardiomyopathy is characterized by an increase in myocardial mass. In order to study the functional significance of myocellular hypertrophy in dilated cardiomyopathy, 40 left ventricular endomyocardial biopsies were investigated, by comparing morphometrical data with functional indexes. The extent of myofibril volume fraction was directly associated with a better functional condition, as measured by ejection fraction (p < 0.01) and cardiac index (p < 0.05). Patients with oversize nuclei (nuclear area being > or = 70 microns 2) had a worse functional status (p < 0.05), as determined by ejection fraction and cardiac index. Finally, the extent of interstitial fibrosis was directly correlated to mean right atrial pressure (p < 0.01), right ventricular end-diastolic pressure (p < 0.02) and mean pulmonary artery pressure (p < 0.02). In conclusion, a worse functional status correlates with a reduced myofibril volume fraction and an oversize nuclear area, as in hypertrophic cells undergoing regressive changes.
1995
Adult; Aged; Biopsy; Cardiac Output; Cardiomyopathy, Dilated; Endocardium; Female; Heart Ventricles; Humans; Hypertrophy; Image Processing, Computer-Assisted; Linear Models; Male; Middle Aged; Myocardium
01 Pubblicazione su rivista::01a Articolo in rivista
Functional significance of myocellular hypertrophy in dilated cardiomyopathy: histomorphometric analysis on 40 endomyocardial biopsies / Gallo, Pietro; Bernucci, P.; D'Amati, Giulia; Cianfrocca, C.; Pelliccia, F.; Marino, Benedetto. - In: THE AMERICAN JOURNAL OF CARDIOVASCULAR PATHOLOGY. - ISSN 0887-8005. - STAMPA. - 5:1(1995), pp. 11-18.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/383224
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