Some theoretical results on the most representative classes of periodic DNAs, characterized by a regular alternation of purine and pyrimidine bases or by sequences with a 10-fold periodicity, are discussed. Z-DNA belongs to the 1st class, whereas periodic synthetic polynucleotides [investigated by J. C. Marini, et al. (1983), H. S. Kov, et al. (1986), and P. J. Hagerman (1986)] and DNAs with a significant periodic sequence fluctuation are among the 2nd class. An attempt is made to clarify some pending questions on the nature of forces determining the Z structure and on the sequence specificity of this conformation, as well as on the mechanism of bending of natural and synthetic DNAs.
Structures and superstructures in periodical polynucleotides / DE SANTIS, Pasquale; Morosetti, Stefano; Palleschi, Antonio; Savino, Maria. - STAMPA. - (1986), pp. 31-49. (Intervento presentato al convegno International Symposium on Structure and Dynamics of nucleic acids, proteins, and membranes. tenutosi a Riva del Garda (TN) nel 31/08-05/09/1986).
Structures and superstructures in periodical polynucleotides
DE SANTIS, Pasquale;MOROSETTI, Stefano;PALLESCHI, Antonio;SAVINO, Maria
1986
Abstract
Some theoretical results on the most representative classes of periodic DNAs, characterized by a regular alternation of purine and pyrimidine bases or by sequences with a 10-fold periodicity, are discussed. Z-DNA belongs to the 1st class, whereas periodic synthetic polynucleotides [investigated by J. C. Marini, et al. (1983), H. S. Kov, et al. (1986), and P. J. Hagerman (1986)] and DNAs with a significant periodic sequence fluctuation are among the 2nd class. An attempt is made to clarify some pending questions on the nature of forces determining the Z structure and on the sequence specificity of this conformation, as well as on the mechanism of bending of natural and synthetic DNAs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
