An anal. of min.-size oligonucleotides assocns. capable of stabilizing the cruciform structure (corresponding to the core of the DNA hairpins) and suitable for x-ray single crystal structure detn. is reported. The conformational anal., carried out by energy minimization and van der Waals potential functions, suggests a structure rather similar to that found in a fragment of tRNA, where H bonds and base pair stacking are maximized.
Modeling of the DNA cruciform core / Calascibetta, Franco Giuseppe; DE SANTIS, Pasquale; Morosetti, Stefano; Palleschi, Antonio; Savino, Maria. - In: GAZZETTA CHIMICA ITALIANA. - ISSN 0016-5603. - STAMPA. - 114:(1984), pp. 437-441.
Modeling of the DNA cruciform core
CALASCIBETTA, Franco Giuseppe;DE SANTIS, Pasquale;MOROSETTI, Stefano;PALLESCHI, Antonio;SAVINO, Maria
1984
Abstract
An anal. of min.-size oligonucleotides assocns. capable of stabilizing the cruciform structure (corresponding to the core of the DNA hairpins) and suitable for x-ray single crystal structure detn. is reported. The conformational anal., carried out by energy minimization and van der Waals potential functions, suggests a structure rather similar to that found in a fragment of tRNA, where H bonds and base pair stacking are maximized.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
