In 15 patients with untreated mild to moderate essential hypertension and left ventricular hypertrophy, we assessed blood pressure, echocardiographic left ventricular mass index, brachial artery compliance (pulsed doppler flowmetry), and calculated forearm vascular resistance (strain gauge plethysmography) before, during (6 and 12 months) and after (1 month washout period) 1 year of satisfactory (blood pressure less-than-or-equal-to 140/90 mm Hg) antihypertensive therapy with the angiotensin-converting enzyme inhibitor trandolapril (2.0 mg orally once daily). During the antihypertensive effective treatment, we observed a significant reduction of systolic and diastolic blood pressures, left ventricular mass index, and forearm vascular resistance at both 6 and 12 months. In addition, brachial artery compliance was significantly increased. After washout, systolic (156 +/- 3 mm Hg) and diastolic (102 +/- 1 mm Hg) blood pressures returned to levels comparable to baseline. However, left ventricular mass index (132 +/- 4; p < 0.01) and brachial artery compliance (1.5 +/- 0.01; p < 0.01) were still different from baseline. These results demonstrate that chronic antihypertensive treatment with trandolapril is associated with a stable regression of cardiac and vascular abnormalities, which is partially unrelated to the blood pressure lowering effect.
REVERSAL OF CARDIAC AND LARGE ARTERY STRUCTURAL ABNORMALITIES INDUCED BY LONG-TERM ANTIHYPERTENSIVE TREATMENT WITH TRANDOLAPRIL / Nicola De, Luca; Giovanni, Rosiello; Fausto, Lamenza; Bruno, Ricciardelli; Raffaele, Marchegiano; Volpe, Massimo; Claudio, Marelli; Bruno, Trimarco. - In: THE AMERICAN JOURNAL OF CARDIOLOGY. - ISSN 0002-9149. - 70:12(1992), pp. D52-D59. (Intervento presentato al convegno SYMP ON SYSTEMIC HYPERTENSION, AT THE 14TH SCIENTIFIC MEETING OF THE INTERNATIONAL SOC OF HYPERTENSION tenutosi a MADRID, SPAIN nel JUN 13, 1992) [10.1016/0002-9149(92)90272-z].
REVERSAL OF CARDIAC AND LARGE ARTERY STRUCTURAL ABNORMALITIES INDUCED BY LONG-TERM ANTIHYPERTENSIVE TREATMENT WITH TRANDOLAPRIL
VOLPE, Massimo;
1992
Abstract
In 15 patients with untreated mild to moderate essential hypertension and left ventricular hypertrophy, we assessed blood pressure, echocardiographic left ventricular mass index, brachial artery compliance (pulsed doppler flowmetry), and calculated forearm vascular resistance (strain gauge plethysmography) before, during (6 and 12 months) and after (1 month washout period) 1 year of satisfactory (blood pressure less-than-or-equal-to 140/90 mm Hg) antihypertensive therapy with the angiotensin-converting enzyme inhibitor trandolapril (2.0 mg orally once daily). During the antihypertensive effective treatment, we observed a significant reduction of systolic and diastolic blood pressures, left ventricular mass index, and forearm vascular resistance at both 6 and 12 months. In addition, brachial artery compliance was significantly increased. After washout, systolic (156 +/- 3 mm Hg) and diastolic (102 +/- 1 mm Hg) blood pressures returned to levels comparable to baseline. However, left ventricular mass index (132 +/- 4; p < 0.01) and brachial artery compliance (1.5 +/- 0.01; p < 0.01) were still different from baseline. These results demonstrate that chronic antihypertensive treatment with trandolapril is associated with a stable regression of cardiac and vascular abnormalities, which is partially unrelated to the blood pressure lowering effect.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
