Together with other modifiable cardiovascular risk factors, hypertension heavily contributes to the global burden of cardiovascular morbidity and mortality, as well as to the increase in individual absolute cardiovascular risk. Comparison of the effectiveness of different therapies in reducing the incidence of major cardiovascular events has classically required the evaluation of major 'hard' end points. In view of the long natural history of hypertension, however, it appears very useful to monitor modifications in measurable 'intermediate' end points or 'disease markers'. This approach may provide more accurate individual risk stratification and a better evaluation of the efficacy of a given treatment in preventing or modifying the course of target organ damage. This may represent a valuable and affordable strategy in clinical practice allowing the evaluation of both patient prognosis and the effectiveness of antihypertensive treatment over time. © 2007 Future Medicine Ltd.

Use of predictive markers to improve cardiovascular protection / Tocci, Giuliano; Paneni, Francesco; Beatrice, Ponziani; Volpe, Massimo. - In: FUTURE CARDIOLOGY. - ISSN 1479-6678. - 3:4(2007), pp. 447-456. [10.2217/14796678.3.4.447]

Use of predictive markers to improve cardiovascular protection

TOCCI, GIULIANO;PANENI, FRANCESCO;VOLPE, Massimo
2007

Abstract

Together with other modifiable cardiovascular risk factors, hypertension heavily contributes to the global burden of cardiovascular morbidity and mortality, as well as to the increase in individual absolute cardiovascular risk. Comparison of the effectiveness of different therapies in reducing the incidence of major cardiovascular events has classically required the evaluation of major 'hard' end points. In view of the long natural history of hypertension, however, it appears very useful to monitor modifications in measurable 'intermediate' end points or 'disease markers'. This approach may provide more accurate individual risk stratification and a better evaluation of the efficacy of a given treatment in preventing or modifying the course of target organ damage. This may represent a valuable and affordable strategy in clinical practice allowing the evaluation of both patient prognosis and the effectiveness of antihypertensive treatment over time. © 2007 Future Medicine Ltd.
2007
cardiovascular events; cardiovascular risk; hypertension; target organ damage
01 Pubblicazione su rivista::01a Articolo in rivista
Use of predictive markers to improve cardiovascular protection / Tocci, Giuliano; Paneni, Francesco; Beatrice, Ponziani; Volpe, Massimo. - In: FUTURE CARDIOLOGY. - ISSN 1479-6678. - 3:4(2007), pp. 447-456. [10.2217/14796678.3.4.447]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/382165
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